Dynamical brain connectivity markers in presymptomatic Alzheimer’s disease
Alzheimer's disease is the most prevalent cause of dementia generally with an onset after the 65 years. However, there are some genetic mutations that induce the onset of the neurocognitive symptoms before that age. The study of mutation carriers provides a unique opportunity to identify early...
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UNIVERSIDAD ANTONIO NARIÑO
2016
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| Online Access: | https://revistas.uan.edu.co/index.php/ingeuan/article/view/408 |
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| author | Suárez-Revelo, Jazmín X. |
| author_facet | Suárez-Revelo, Jazmín X. |
| author_sort | Suárez-Revelo, Jazmín X. |
| collection | OJS |
| description | Alzheimer's disease is the most prevalent cause of dementia generally with an onset after the 65 years. However, there are some genetic mutations that induce the onset of the neurocognitive symptoms before that age. The study of mutation carriers provides a unique opportunity to identify early preclinical changes related to Alzheimer's disease. The Event Related Potentials are a powerful tool used for the study of the neural substrates of cognitive function and deterioration. The connectivity analysis emerges as an alternative to the average approach typical in Event Related Potentials. In the current work two groups, mutation carriers and non-carriers, perform a memory task during Electroencephalography recording. Brain graphs are built at different time points using the directed Direct Transfer Function. Our results show how the dynamical study of the connectivity might help to detect neuronal changes in preclinical stage of Alzheimer's disease. |
| format | Digital |
| id | revistas.uan.edu.co-article-408 |
| institution | Revista INGE@UAN |
| language | spa |
| publishDate | 2016 |
| publisher | UNIVERSIDAD ANTONIO NARIÑO |
| record_format | ojs |
| spelling | revistas.uan.edu.co-article-4082021-03-11T14:05:02Z Dynamical brain connectivity markers in presymptomatic Alzheimer’s disease Suárez-Revelo, Jazmín X. Alzheimer's disease is the most prevalent cause of dementia generally with an onset after the 65 years. However, there are some genetic mutations that induce the onset of the neurocognitive symptoms before that age. The study of mutation carriers provides a unique opportunity to identify early preclinical changes related to Alzheimer's disease. The Event Related Potentials are a powerful tool used for the study of the neural substrates of cognitive function and deterioration. The connectivity analysis emerges as an alternative to the average approach typical in Event Related Potentials. In the current work two groups, mutation carriers and non-carriers, perform a memory task during Electroencephalography recording. Brain graphs are built at different time points using the directed Direct Transfer Function. Our results show how the dynamical study of the connectivity might help to detect neuronal changes in preclinical stage of Alzheimer's disease. UNIVERSIDAD ANTONIO NARIÑO 2016-02-24 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://revistas.uan.edu.co/index.php/ingeuan/article/view/408 INGE@UAN - TENDENCIAS EN LA INGENIERÍA; Vol. 6 Núm. 11 (2015) 2346-1446 2145-0935 spa https://revistas.uan.edu.co/index.php/ingeuan/article/view/408/343 https://creativecommons.org/licenses/by-nc-sa/4.0 |
| spellingShingle | Suárez-Revelo, Jazmín X. Dynamical brain connectivity markers in presymptomatic Alzheimer’s disease |
| title | Dynamical brain connectivity markers in presymptomatic Alzheimer’s disease |
| title_full | Dynamical brain connectivity markers in presymptomatic Alzheimer’s disease |
| title_fullStr | Dynamical brain connectivity markers in presymptomatic Alzheimer’s disease |
| title_full_unstemmed | Dynamical brain connectivity markers in presymptomatic Alzheimer’s disease |
| title_short | Dynamical brain connectivity markers in presymptomatic Alzheimer’s disease |
| title_sort | dynamical brain connectivity markers in presymptomatic alzheimer s disease |
| url | https://revistas.uan.edu.co/index.php/ingeuan/article/view/408 |
| work_keys_str_mv | AT suarezrevelojazminx dynamicalbrainconnectivitymarkersinpresymptomaticalzheimersdisease |
