Efectos adversos corneales del uso de los AINES oculares
Topical ophthalmic non-steroidal anti-inflammatory drugs (NSAIDs) are a group of drugs that combine therapeutic effects and adverse effects; contributing analgesic, anti-inflammatory and antipyretic properties (1). They are formulated after surgical procedures such as keratoplasty, cataract extracti...
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Universidad Antonio Nariño
2022
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| author | Panesso Palacios, Nardy Kamerlin Jaramillo Salazar, Stefania Montoya Herrera, Sandra Milena |
| author2 | Cortés Rodríguez, Diana Catalina |
| author_facet | Cortés Rodríguez, Diana Catalina Panesso Palacios, Nardy Kamerlin Jaramillo Salazar, Stefania Montoya Herrera, Sandra Milena |
| author_sort | Panesso Palacios, Nardy Kamerlin |
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| description | Topical ophthalmic non-steroidal anti-inflammatory drugs (NSAIDs) are a group of drugs that combine therapeutic effects and adverse effects; contributing analgesic, anti-inflammatory and antipyretic properties (1). They are formulated after surgical procedures such as keratoplasty, cataract extraction, refractive surgery, and for the control of inflammatory-type ocular surface disorders. Furthermore, his activity anti-inflammatory lies in the inhibition of the enzyme cyclooxygenase (COX) in its isoforms like COX-1 and COX-2, the first is a physiological form that is found naturally common in the kidney, intestinal tract, monocytes/macrophages and platelets. It is expressed in formation of essential prostaglandins (2). The action of NSAIDs is to generate a reversible inhibition of these enzymes in order to to slow down the formation of prostaglandins whose action is to mediate the processes inflammatory. In contrast, COX-2 is almost undetectable in normal tissues, its manifestation is given by the release of some inflammatory-type prostaglandins, which lead to the appearance of inflammatory mechanisms and the amplification of signals painful in the inflamed areas(3). |
| format | Trabajo de grado (Pregrado y/o Especialización) |
| id | repositorio.uan.edu.co-123456789-6541 |
| institution | Repositorio Digital UAN |
| language | spa |
| publishDate | 2022 |
| publisher | Universidad Antonio Nariño |
| record_format | dspace |
| spelling | repositorio.uan.edu.co-123456789-65412024-10-09T22:44:37Z Efectos adversos corneales del uso de los AINES oculares Panesso Palacios, Nardy Kamerlin Jaramillo Salazar, Stefania Montoya Herrera, Sandra Milena Cortés Rodríguez, Diana Catalina Galeano Castañeda, Yadira Bernarda Ketorolaco Diclofenaco Bromfenaco, Superficie ocular Efectos adversos Antiinflamatorios no esteroideos Cirugia de catarata Ketorolac Diclofenac Bromfenac Ocular surface Adverse effects Non-steroidal anti-inflammatory drugs Cataract surgery Topical ophthalmic non-steroidal anti-inflammatory drugs (NSAIDs) are a group of drugs that combine therapeutic effects and adverse effects; contributing analgesic, anti-inflammatory and antipyretic properties (1). They are formulated after surgical procedures such as keratoplasty, cataract extraction, refractive surgery, and for the control of inflammatory-type ocular surface disorders. Furthermore, his activity anti-inflammatory lies in the inhibition of the enzyme cyclooxygenase (COX) in its isoforms like COX-1 and COX-2, the first is a physiological form that is found naturally common in the kidney, intestinal tract, monocytes/macrophages and platelets. It is expressed in formation of essential prostaglandins (2). The action of NSAIDs is to generate a reversible inhibition of these enzymes in order to to slow down the formation of prostaglandins whose action is to mediate the processes inflammatory. In contrast, COX-2 is almost undetectable in normal tissues, its manifestation is given by the release of some inflammatory-type prostaglandins, which lead to the appearance of inflammatory mechanisms and the amplification of signals painful in the inflamed areas(3). Los antiinflamatorios no esteroideos (AINES) oftálmicos tópicos son un grupo de fármacos que combinan efectos terapéuticos y efectos adversos; aportando propiedades analgésicas, antiinflamatorias y antipiréticas (1). Son formulados despues de procedimientos quirúrgicos como queratoplastias, extracción de cataratas, cirugía refractiva y para control de trastornos de la superficie ocular de tipo inflamatorio. Además, su actividad antiinflamatorio radica en la inhibición de la enzima ciclooxigenasa (COX) en sus isoformas como la COX-1 y COX-2, la primera es una forma fisiológica que se encuentra de manera habitual en el riñón, tracto intestinal, monocitos/macrófagos y plaquetas. Se expresa en la formación de prostaglandinas esenciales (2). El accionar de los AINES es generar una inhibición reversible de estas enzimas con el fin de aminorar la formación de las prostaglandinas cuya acción es mediar los procesos inflamatorios. En contraposición la COX-2 es casi indetectable en tejidos normales, su manifestación se da por la liberación de algunas prostaglandinas de tipo inflamatorio, las cuales conducen a la aparición de mecanismos inflamatorios y a la amplificación de las señales dolorosas en las zonas inflamadas(3). Optómetra Pregrado Presencial Monografía 2022-05-14T14:03:23Z 2022-05-14T14:03:23Z 2021-11-22 Trabajo de grado (Pregrado y/o Especialización) info:eu-repo/semantics/acceptedVersion http://purl.org/coar/resource_type/c_7a1f http://purl.org/coar/version/c_970fb48d4fbd8a85 http://repositorio.uan.edu.co/handle/123456789/6541 Fabbiani S, Garafoni F, Catenaccio V, Speranza N. Eficacia y seguridad de los AINE tópicos [Internet]. Rev. urug. med. interna. 2019 [citado 17 de septiembre de 2020]. p. 7. Disponible en: http://www.scielo.edu.uy/pdf/rumi/v4n3/2393-6797-rumi-4-03-8.pdf AINEs en inflamación ocular. Schoenberger SD, Kim SJ. Nonsteroidal anti-inflammatory drugs for retinal disease [Internet]. Vol. 2013, International Journal of Inflammation. Hindawi Limited; 2013 [citado 17 de septiembre de 2020]. Disponible en: /pmc/articles/PMC3556848/?report=abstract Khalifa YM, Mifflin MD. Keratitis and corneal melt with ketorolac tromethamine after conductive keratoplasty. Cornea [Internet]. abril de 2011 [citado 21 de octubre de 2020];30(4):477-8. Disponible en: https://pubmed.ncbi.nlm.nih.gov/21099410/ Prasher P. Acute corneal melt associated with topical bromfenac use. Eye Contact Lens [Internet]. julio de 2012 [citado 16 de septiembre de 2020];38(4):260-2. Disponible en: https://pubmed.ncbi.nlm.nih.gov/22169877/ Kawahara A, Utsunomiya T, Kato Y, Takayanagi Y. Comparison of effect of nepafenac and diclofenac ophthalmic solutions on cornea, tear film, and ocular surface after cataract surgery: the results of a randomized trial. Clin Ophthalmol [Internet]. 4 de marzo de 2016 [citado 17 de septiembre de 2020];10:385. Disponible en: https://www.dovepress.com/comparison-of-effect-of-nepafenac-and-diclofenacophthalmic-solutions--peer-reviewed-article-OPTH Jesus J, Almeida I, Soares R, Geraldes R, Chibante-Pedro J. Corneal perforation associated with the use of ketorolac tromethamine after cataract surgery. J EuCornea. 1 de abril de 2020;6:1-3. Benedi, Juana; Romero C. Terapia antiinflamatoria tópica | Farmacia Profesional [Internet]. [citado 17 de septiembre de 2020]. Disponible en: https://www.elsevier.es/esrevista-farmacia-profesional-3-articulo-terapia-antiinflamatoria-topica-13088393 Conociendo las estructuras del ojo-blog-CLÍNICA VALLE I Nicaragua. [Internet]. [citado 9 de octubre de 2020]. Disponible en: https://clinicavalle.com/blog/el-ojo-estructuras-yfunciones/ Blefaroplastia o cirugia de parpados [Internet]. [citado 19 de febrero de 2021]. Disponible en: https://blefaroplastiaweb.com/ instname:Universidad Antonio Nariño reponame:Repositorio Institucional UAN repourl:https://repositorio.uan.edu.co/ spa Acceso abierto Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess http://purl.org/coar/access_right/c_abf2 application/pdf application/pdf application/pdf Universidad Antonio Nariño Optometría Facultad de Optometría Medellín |
| spellingShingle | Ketorolaco Diclofenaco Bromfenaco, Superficie ocular Efectos adversos Antiinflamatorios no esteroideos Cirugia de catarata Ketorolac Diclofenac Bromfenac Ocular surface Adverse effects Non-steroidal anti-inflammatory drugs Cataract surgery Panesso Palacios, Nardy Kamerlin Jaramillo Salazar, Stefania Montoya Herrera, Sandra Milena Efectos adversos corneales del uso de los AINES oculares |
| title | Efectos adversos corneales del uso de los AINES oculares |
| title_full | Efectos adversos corneales del uso de los AINES oculares |
| title_fullStr | Efectos adversos corneales del uso de los AINES oculares |
| title_full_unstemmed | Efectos adversos corneales del uso de los AINES oculares |
| title_short | Efectos adversos corneales del uso de los AINES oculares |
| title_sort | efectos adversos corneales del uso de los aines oculares |
| topic | Ketorolaco Diclofenaco Bromfenaco, Superficie ocular Efectos adversos Antiinflamatorios no esteroideos Cirugia de catarata Ketorolac Diclofenac Bromfenac Ocular surface Adverse effects Non-steroidal anti-inflammatory drugs Cataract surgery |
| url | http://repositorio.uan.edu.co/handle/123456789/6541 |
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