Efectos adversos corneales del uso de los AINES oculares
Topical ophthalmic non-steroidal anti-inflammatory drugs (NSAIDs) are a group of drugs that combine therapeutic effects and adverse effects; contributing analgesic, anti-inflammatory and antipyretic properties (1). They are formulated after surgical procedures such as keratoplasty, cataract extracti...
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| Autores principales: | , , |
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| Otros Autores: | |
| Formato: | Trabajo de grado (Pregrado y/o Especialización) |
| Lenguaje: | spa |
| Publicado: |
Universidad Antonio Nariño
2022
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| Materias: | |
| Acceso en línea: | http://repositorio.uan.edu.co/handle/123456789/6541 |
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| Sumario: | Topical ophthalmic non-steroidal anti-inflammatory drugs (NSAIDs) are a group of drugs that combine therapeutic effects and adverse effects; contributing analgesic, anti-inflammatory and antipyretic properties (1). They are formulated after surgical procedures such as keratoplasty, cataract extraction, refractive surgery, and for the control of inflammatory-type ocular surface disorders. Furthermore, his activity anti-inflammatory lies in the inhibition of the enzyme cyclooxygenase (COX) in its isoforms like COX-1 and COX-2, the first is a physiological form that is found naturally common in the kidney, intestinal tract, monocytes/macrophages and platelets. It is expressed in formation of essential prostaglandins (2). The action of NSAIDs is to generate a reversible inhibition of these enzymes in order to to slow down the formation of prostaglandins whose action is to mediate the processes inflammatory. In contrast, COX-2 is almost undetectable in normal tissues, its manifestation is given by the release of some inflammatory-type prostaglandins, which lead to the appearance of inflammatory mechanisms and the amplification of signals painful in the inflamed areas(3). |
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