Relación entre Unidades Discretas de Tipificación de Trypanosoma cruzi y la enfermedad de Chagas

The protozoan Trypanosoma cruzi is the causative agent of Chagas disease and is considered one of the major health problems in South America. Molecular studies exhibit this parasite has a wide genetic diversity, being classified into six discrete typing units (Tc I - VI) and other related to bats (T...

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Main Author:	Rodríguez Acosta, Anyi Lorena
Other Authors:	Bernal Rosas, Yuly Elien
Format:	Trabajo de grado (Pregrado y/o Especialización)
Language:	spa
Published:	Universidad Antonio Nariño 2022
Subjects:	Enfermedad de Chagas Triatominos Trypanosoma cruzi Unidades discretas de tipificación (UDTs). 540 Chagas disease Triatomines Discrete typing unit (DTU)
Online Access:	http://repositorio.uan.edu.co/handle/123456789/6377
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author	Rodríguez Acosta, Anyi Lorena
author2	Bernal Rosas, Yuly Elien
author_facet	Bernal Rosas, Yuly Elien Rodríguez Acosta, Anyi Lorena
author_sort	Rodríguez Acosta, Anyi Lorena
collection	DSpace
description	The protozoan Trypanosoma cruzi is the causative agent of Chagas disease and is considered one of the major health problems in South America. Molecular studies exhibit this parasite has a wide genetic diversity, being classified into six discrete typing units (Tc I - VI) and other related to bats (T Bat). This parasite has a high clinical and genetic diversity; but its immunopathogenesis is still quite unknown. It should be noted that the pathogenicity of some strains differs in their mechanism of infection and spread according to the host, which makes it difficult to predict the results of the disease. Therefore, a bibliographic search was carried for evidence published in various information sources was carried out, during the period 2015 to 2021, in order to obtain the most up-to-date data on research advances related to the genetic variability of the parasite associated with its geographical distribution, vectors, reservoirs and finally the clinical manifestations in people. The findings of this bibliographic review allowed us to conclude that the great plasticity, virulence of the parasite and the immune response of the hosts are determinants that influence the distribution of the different discrete typing units and the presentation of clinical pictures.
format	Trabajo de grado (Pregrado y/o Especialización)
id	repositorio.uan.edu.co-123456789-6377
institution	Repositorio Digital UAN
language	spa
publishDate	2022
publisher	Universidad Antonio Nariño
record_format	dspace
spelling	repositorio.uan.edu.co-123456789-63772024-10-09T22:58:25Z Relación entre Unidades Discretas de Tipificación de Trypanosoma cruzi y la enfermedad de Chagas Rodríguez Acosta, Anyi Lorena Bernal Rosas, Yuly Elien Torres García, Orlando Alfredo Enfermedad de Chagas Triatominos Trypanosoma cruzi Unidades discretas de tipificación (UDTs). 540 Chagas disease Triatomines Trypanosoma cruzi Discrete typing unit (DTU) The protozoan Trypanosoma cruzi is the causative agent of Chagas disease and is considered one of the major health problems in South America. Molecular studies exhibit this parasite has a wide genetic diversity, being classified into six discrete typing units (Tc I - VI) and other related to bats (T Bat). This parasite has a high clinical and genetic diversity; but its immunopathogenesis is still quite unknown. It should be noted that the pathogenicity of some strains differs in their mechanism of infection and spread according to the host, which makes it difficult to predict the results of the disease. Therefore, a bibliographic search was carried for evidence published in various information sources was carried out, during the period 2015 to 2021, in order to obtain the most up-to-date data on research advances related to the genetic variability of the parasite associated with its geographical distribution, vectors, reservoirs and finally the clinical manifestations in people. The findings of this bibliographic review allowed us to conclude that the great plasticity, virulence of the parasite and the immune response of the hosts are determinants that influence the distribution of the different discrete typing units and the presentation of clinical pictures. El protozoario Trypanosoma cruzi es el agente causal de la enfermedad de Chagas y se considera uno de los mayores problemas de salud en Sudamérica. Estudios moleculares han demostrado que este parásito presenta una amplia diversidad genética, clasificándose en seis unidades discretas de tipificación (Tc I – VI) y una más, relacionada con murciélagos (T Bat). Este parásito presenta una alta diversidad clínica y genética, pero su inmunopatogénesis aún es bastante desconocida. La patogenicidad de algunas cepas difiere en su mecanismo de infección y propagación según el hospedero, lo que dificulta la predicción de los resultados de la enfermedad. A partir de ello se realizó una búsqueda bibliográfica de evidencia publicada en diversas fuentes de información, durante el periodo 2015 a 2021, con el fin de obtener los datos más actualizados sobre los avances investigativos relacionados con la variabilidad genética del parásito relacionado a su distribución geográfica, vectores, reservorios y finalmente a las manifestaciones clínicas que presentan las personas infectadas. Los hallazgos de esta revisión bibliográfica permitieron concluir que la gran plasticidad, la virulencia del parásito y la respuesta inmune de los hospederos son determinantes que influyen en la distribución de las diferentes unidades discretas de tipificación y la presentación de los cuadros clínicos. Bioquímico(a) Pregrado Presencial Monografía 2022-04-30T01:07:27Z 2022-04-30T01:07:27Z 2021-11-23 Trabajo de grado (Pregrado y/o Especialización) info:eu-repo/semantics/acceptedVersion http://purl.org/coar/resource_type/c_7a1f http://purl.org/coar/version/c_970fb48d4fbd8a85 http://repositorio.uan.edu.co/handle/123456789/6377 Abarca, H., Trubnykova, M., Chavesta, F., Ordoñez, M., & Rondón, E. (2021). Variantes en el número de copias en neonatos aneuploides. Biomedica, 41, 282–292. https://doi.org/10.7705/biomedica.5354 Abras, A., Muñoz, C., Juiz, N. A., Carlos, J., Cura, C. I., Tebar, S., Fernández-arévalo, A., Pinazo, M., De, L., Posada, E., Navarro, F., Espinal, P., Ballart, C., Gascón, J., & Schijman, A. G. (2017). Parasitology International Identi fi cation of Trypanosoma cruzi Discrete Typing Units ( DTUs ) in Latin-American migrants in Barcelona ( Spain ). Parasitology International, 66(2), 83–88. https://doi.org/10.1016/j.parint.2016.12.003 Almeida, L., Vasconcelos, S. De, Oliveira, J. C., Allan, G., Augusto, J., Guerra, D. O., Vale, G., & Guerra, B. (2021). Case Report Trypanosoma cruzi discrete typing unit TcIV implicated in a case of acute Chagas disease in a domiciliated dog in the western Amazon. Revista Da Sociedade Brasileira de Medicina Tropica, 54, 1–4. Andrés, R., Díaz, C., Forsyth, C., Alberto, O., Marchiol, A., Beltrán, M., Batista, C., Herazo, R., Javier, M., Pachon, E., Valencia-hernández, C. A., Carolina, A., & Sánchez, F. (2019). International Journal of Infectious Diseases Comparative evaluation of immunoassays to improve access to diagnosis for Chagas disease in Colombia. International Journal of Infectious Diseases, 87, 100–108. https://doi.org/10.1016/j.ijid.2019.07.022 Anónimo. (1999). Recommendations from a satellite meeting. Internartional Symposium to commemorate the 90th anniversary of the discovery of chagas disease, Rio de Janeiro,Brazil. Memorias Do Instituto Oswaldo Cruz, 94 Suppl 1, 429–432. Avispas, M. (2019). Control biológico de vectores de la enfermedad de Chagas con Microhimenopteros (Micro Avispas). 7, 85–93. Balouz, V., Camea, C. C., Cori, C., Kashiwagi, G. A., Gil, S. A., Paula, N., Macchiaverna, N. P., Cardinal, M. V., Guaimas, F., Lobo, M., Lederkremer, R. M., Gallo-rodriguez, C., & Buscaglia, C. A. (2019). Trypanosoma cruzi surface mucins are involved in the attachment to the Triatoma infestans rectal ampoule. 1–23. Barja, M. R., Rus, L. I., Boquete, T., Benito, A., & Hernández, T. B. (2021). Key Chagas disease missing knowledge among at ‑ risk population in Spain affecting diagnosis and treatment. Infectious Diseases of Poverty, 1–11. https://doi.org/10.1186/s40249-021- 00841-4 Barnabé, C., Mobarec, H. I., Jurado, M. R., Cortez, J. A., & Brenière, S. F. (2016). Reconsideration of the seven discrete typing units within the species Trypanosoma cruzi, a new proposal of three reliable mitochondrial clades. Infection, Genetics and Evolution, 39, 176–186. https://doi.org/10.1016/j.meegid.2016.01.029 Barros, J. H. S., Xavier, S. C. C., Bilac, D., Lima, V. S., Dario, M. A., & Jansen, A. M. (2017). Identification of novel mammalian hosts and Brazilian biome geographic distribution of Trypanosoma cruzi TcIII and TcIV. Acta Tropica, 172(May), 173–179. https://doi.org/10.1016/j.actatropica.2017.05.003 instname:Universidad Antonio Nariño reponame:Repositorio Institucional UAN repourl:https://repositorio.uan.edu.co/ spa Acceso abierto Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) https://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess http://purl.org/coar/access_right/c_abf2 application/pdf application/pdf application/pdf Universidad Antonio Nariño Bioquímica Facultad de Ciencias Bogotá - Circunvalar
spellingShingle	Enfermedad de Chagas Triatominos Trypanosoma cruzi Unidades discretas de tipificación (UDTs). 540 Chagas disease Triatomines Trypanosoma cruzi Discrete typing unit (DTU) Rodríguez Acosta, Anyi Lorena Relación entre Unidades Discretas de Tipificación de Trypanosoma cruzi y la enfermedad de Chagas
title	Relación entre Unidades Discretas de Tipificación de Trypanosoma cruzi y la enfermedad de Chagas
title_full	Relación entre Unidades Discretas de Tipificación de Trypanosoma cruzi y la enfermedad de Chagas
title_fullStr	Relación entre Unidades Discretas de Tipificación de Trypanosoma cruzi y la enfermedad de Chagas
title_full_unstemmed	Relación entre Unidades Discretas de Tipificación de Trypanosoma cruzi y la enfermedad de Chagas
title_short	Relación entre Unidades Discretas de Tipificación de Trypanosoma cruzi y la enfermedad de Chagas
title_sort	relacion entre unidades discretas de tipificacion de trypanosoma cruzi y la enfermedad de chagas
topic	Enfermedad de Chagas Triatominos Trypanosoma cruzi Unidades discretas de tipificación (UDTs). 540 Chagas disease Triatomines Trypanosoma cruzi Discrete typing unit (DTU)
url	http://repositorio.uan.edu.co/handle/123456789/6377
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