Rol de la Microglía en el desarrollo del Glioblastoma
Glioblastoma multiforme is one of the most aggressive brain cancers, with an average survival of less than 15 months. Its high proliferation, invasion and suppression capacity immune make it resistant to chemotherapy, radiotherapy and surgery. what drives development of new therapies. A key factor...
Guardado en:
| Autor principal: | |
|---|---|
| Otros Autores: | |
| Formato: | Tesis/Trabajo de grado - Monografía - Pregrado |
| Lenguaje: | Español |
| Publicado: |
Universidad Antonio Nariño
2024
|
| Materias: | |
| Acceso en línea: | https://repositorio.uan.edu.co/handle/123456789/11843 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| _version_ | 1824086885303058432 |
|---|---|
| author | Gómez Rivas Gabriel Nicolas |
| author2 | Losada Barragán, Mónica |
| author_facet | Losada Barragán, Mónica Gómez Rivas Gabriel Nicolas |
| author_sort | Gómez Rivas Gabriel Nicolas |
| collection | DSpace |
| description | Glioblastoma multiforme is one of the most aggressive brain cancers, with an average survival of less than 15 months. Its high proliferation, invasion and suppression capacity immune make it resistant to chemotherapy, radiotherapy and surgery. what drives development of new therapies. A key factor in its lethality is its tumor microenvironment, which is consisting mainly of the tumor and microglia. Microglia are exclusive macrophages of the central nervous system which serves as the main defender against an infection or signs of damage, through phagocytosis and pro-inflammatory or anti-inflammatory mechanisms depending on the severity and status of the infection or injury. |
| format | Tesis/Trabajo de grado - Monografía - Pregrado |
| id | repositorio.uan.edu.co-123456789-11843 |
| institution | Repositorio Digital UAN |
| language | Español |
| publishDate | 2024 |
| publisher | Universidad Antonio Nariño |
| record_format | dspace |
| spelling | repositorio.uan.edu.co-123456789-118432024-11-23T16:34:50Z Rol de la Microglía en el desarrollo del Glioblastoma Gómez Rivas Gabriel Nicolas Losada Barragán, Mónica Microglia, Glioblastoma Angiogenesis Evasión Immune Microglia, Glioblastoma Angiogenesis Immune Evasion Glioblastoma multiforme is one of the most aggressive brain cancers, with an average survival of less than 15 months. Its high proliferation, invasion and suppression capacity immune make it resistant to chemotherapy, radiotherapy and surgery. what drives development of new therapies. A key factor in its lethality is its tumor microenvironment, which is consisting mainly of the tumor and microglia. Microglia are exclusive macrophages of the central nervous system which serves as the main defender against an infection or signs of damage, through phagocytosis and pro-inflammatory or anti-inflammatory mechanisms depending on the severity and status of the infection or injury. El glioblastoma multiforme es uno de los cánceres cerebrales más agresivos, con una media de supervivencia inferior a los 15 meses. Su alta proliferación, invasión y capacidad de supresión inmune lo hacen resistente a la quimioterapia, radioterapia y cirugía. lo que impulsa el desarrollo de nuevas terapias. Un factor clave en su letalidad es su microambiente tumoral, el cual, está constituido principalmente por el tumor y la microglía. La microglía es un macrófago exclusivo del sistema nervioso central el cual funge como principal defensor ante una infección o señales de daño, por medio fagocitosis y mecanismos proinflamatorios o antiinflamatorios dependiendo de la gravedad y estado de la infección o la lesión. final Biotecnólogo(a) Pregrado Presencial Monografía 2024-11-13T16:42:31Z 2024-11-13T16:42:31Z 2024-06-26 2024-11-13 Tesis/Trabajo de grado - Monografía - Pregrado Estudio descriptivo Versión original del autor, Borrador, Manuscrito http://purl.org/redcol/resource_type/PIC http://purl.org/coar/version/c_b1a7d7d4d402bcce https://repositorio.uan.edu.co/handle/123456789/11843 Español Acceso cerrado http://purl.org/coar/access_right/c_16ec pdf application/pdf application/pdf application/pdf Universidad Antonio Nariño Biotecnología Facultad de Ciencias Bogotá - Circunvalar instname:Universidad Antonio Nariño Ahir, B. K., Engelhard, H. H., & Lakka, S. S. (2020). Tumor Development and Angiogenesis in Adult Brain Tumor: Glioblastoma. In Molecular Neurobiology (Vol. 57, Issue 5, pp. 2461–2478). Springer. https://doi.org/10.1007/s12035-020-01892-8 Albakova, Z., Mangasarova, Y., Albakov, A., & Gorenkova, L. (2022). HSP70 and HSP90 in Cancer: Cytosolic, Endoplasmic Reticulum and Mitochondrial Chaperones of Tumorigenesis. In Frontiers in Oncology (Vol. 12). Frontiers Media S.A. https://doi.org/10.3389/fonc.2022.829520 Allen, N. J., & Lyons, D. A. (n.d.). Glia as architects of central nervous system formation and function. http://science.sciencemag.org/ Andersen, R. S., Anand, A., Harwood, D. S. L., & Kristensen, B. W. (2021). Tumorassociated microglia and macrophages in the glioblastoma microenvironment and their implications for therapy. In Cancers (Vol. 13, Issue 17). MDPI AG. https://doi.org/10.3390/cancers13174255 Blitz, S. E., Kappel, A. D., Gessler, F. A., Klinger, N. V., Arnaout, O., Lu, Y., Peruzzi, P. P., Smith, T. R., Chiocca, E. A., Friedman, G. K., & Bernstock, J. D. (2022). TumorAssociated Macrophages/Microglia in Glioblastoma Oncolytic Virotherapy: A DoubleEdged Sword. In International Journal of Molecular Sciences (Vol. 23, Issue 3). MDPI. https://doi.org/10.3390/ijms23031808 Buonfiglioli, A., & Hambardzumyan, D. (2021). Macrophages and microglia: the cerberus of glioblastoma. In Acta Neuropathologica Communications (Vol. 9, Issue 1). BioMed Central Ltd. https://doi.org/10.1186/s40478-021-01156-z Cloughesy, T. F., Mochizuki, A. Y., Orpilla, J. R., Hugo, W., Lee, A. H., Davidson, T. B., Wang, A. C., Ellingson, B. M., Rytlewski, J. A., Sanders, C. M., Kawaguchi, E. S., Du, L., Li, G., Yong, W. H., Gaffey, S. C., Cohen, A. L., Mellinghoff, I. K., Lee, E. Q., Reardon, D. A., … Prins, R. M. (2019). Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma. Nature Medicine, 25(3), 477–486. https://doi.org/10.1038/s41591-018-0337-7 Codrici, E., Popescu, I. D., Tanase, C., & Enciu, A. M. (2022). Friends with Benefits: Chemokines, Glioblastoma-Associated Microglia/Macrophages and Tumor Microenvironment. In International Journal of Molecular Sciences (Vol. 23, Issue 5). MDPI. https://doi.org/10.3390/ijms23052509 De Leo, A., Ugolini, A., & Veglia, F. (2021). Myeloid cells in glioblastoma microenvironment. In Cells (Vol. 10, Issue 1, pp. 1–20). MDPI. https://doi.org/10.3390/cells10010018 Dinarello, C. A. (2011). Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. Blood, 117(14), 3720–3732. https://doi.org/10.1182/blood-2010-07-273417 |
| spellingShingle | Microglia, Glioblastoma Angiogenesis Evasión Immune Microglia, Glioblastoma Angiogenesis Immune Evasion Gómez Rivas Gabriel Nicolas Rol de la Microglía en el desarrollo del Glioblastoma |
| title | Rol de la Microglía en el desarrollo del Glioblastoma |
| title_full | Rol de la Microglía en el desarrollo del Glioblastoma |
| title_fullStr | Rol de la Microglía en el desarrollo del Glioblastoma |
| title_full_unstemmed | Rol de la Microglía en el desarrollo del Glioblastoma |
| title_short | Rol de la Microglía en el desarrollo del Glioblastoma |
| title_sort | rol de la microglia en el desarrollo del glioblastoma |
| topic | Microglia, Glioblastoma Angiogenesis Evasión Immune Microglia, Glioblastoma Angiogenesis Immune Evasion |
| url | https://repositorio.uan.edu.co/handle/123456789/11843 |
| work_keys_str_mv | AT gomezrivasgabrielnicolas roldelamicrogliaeneldesarrollodelglioblastoma |
