Protein fibrillation: the good, the bad and the ugly
Protein fibrillation is a process in which the peptide chains are slightly modified form native structure to yield fibers. The mechanism that leads to this fiber conformations is little known. An accepted hypothesis is the “entropic cone”, according to this hypothesis a pre-unfolded structure plays...
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UNIVERSIDAD ANTONIO NARIÑO
2020
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| Online Access: | https://revistas.uan.edu.co/index.php/saywa/article/view/674 https://repositorio.uan.edu.co/handle/123456789/11090 |
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| author | Segura, Karen Malagón, Edwin Andres |
| author_facet | Segura, Karen Malagón, Edwin Andres |
| author_sort | Segura, Karen |
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| description | Protein fibrillation is a process in which the peptide chains are slightly modified form native structure to yield fibers. The mechanism that leads to this fiber conformations is little known. An accepted hypothesis is the “entropic cone”, according to this hypothesis a pre-unfolded structure plays a crucial role in the fiber growth. Fibrillation can offer certain advantages, since the new structure offers technological possibilities. On the other hand, when the process occurs inside tissues could be responsible to generate a series of illness known as “amyloidosis”. At the University Antonio Nariño a family of macrocyclic molecules, the resorcinarenes, is been studied. Preliminary results indicate that thismacrocycles are able to inhibit the fibrillation of certain proteins. |
| format | info:eu-repo/semantics/article |
| id | repositorio.uan.edu.co-123456789-11090 |
| institution | Repositorio Digital UAN |
| language | spa |
| publishDate | 2020 |
| publisher | UNIVERSIDAD ANTONIO NARIÑO |
| record_format | dspace |
| spelling | repositorio.uan.edu.co-123456789-110902024-10-14T03:46:03Z Protein fibrillation: the good, the bad and the ugly Fibrilación de proteínas: Lo bueno, lo malo y lo feo Segura, Karen Malagón, Edwin Andres Protein fibrillation is a process in which the peptide chains are slightly modified form native structure to yield fibers. The mechanism that leads to this fiber conformations is little known. An accepted hypothesis is the “entropic cone”, according to this hypothesis a pre-unfolded structure plays a crucial role in the fiber growth. Fibrillation can offer certain advantages, since the new structure offers technological possibilities. On the other hand, when the process occurs inside tissues could be responsible to generate a series of illness known as “amyloidosis”. At the University Antonio Nariño a family of macrocyclic molecules, the resorcinarenes, is been studied. Preliminary results indicate that thismacrocycles are able to inhibit the fibrillation of certain proteins. Los procesos de fibrilación de proteínas se refieren a la unión de cadenas ligeramente modificadas en su estructura nativa, formando pequeñas fibras. Se conoce poco acerca del mecanismo que conduce a estas conformaciones, una hipótesis difundida y aceptada es la del cono entrópico, según la cual una estructura pre-desplegada es crucial en el crecimiento de fibras. La fibrilación puede presentar ventajas en cuanto a que las proteínas así conformadas tienen cualidades aprovechables tecnológicamente. Por otra parte, si el proceso ocurre en tejidos podría generar enfermedades conocidas como amiloidosis. En la Universidad Antonio Nariño se han estudiado moléculas macrocíclicas tipo resorcinareno capaces de inhibir la fibrilación de algunas proteínas. 2020-03-20 2024-10-10T02:54:54Z 2024-10-10T02:54:54Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Divulgación científica http://purl.org/coar/resource_type/c_6501 http://purl.org/coar/version/c_970fb48d4fbd8a85 https://revistas.uan.edu.co/index.php/saywa/article/view/674 https://repositorio.uan.edu.co/handle/123456789/11090 spa https://revistas.uan.edu.co/index.php/saywa/article/view/674/574 https://creativecommons.org/licenses/by-nc-sa/4.0 http://purl.org/coar/access_right/c_abf2 application/pdf UNIVERSIDAD ANTONIO NARIÑO REVISTA SAYWA; Vol. 1 Núm. 1 (2019) 2744-8576 2711-1571 |
| spellingShingle | Segura, Karen Malagón, Edwin Andres Protein fibrillation: the good, the bad and the ugly |
| title | Protein fibrillation: the good, the bad and the ugly |
| title_full | Protein fibrillation: the good, the bad and the ugly |
| title_fullStr | Protein fibrillation: the good, the bad and the ugly |
| title_full_unstemmed | Protein fibrillation: the good, the bad and the ugly |
| title_short | Protein fibrillation: the good, the bad and the ugly |
| title_sort | protein fibrillation the good the bad and the ugly |
| url | https://revistas.uan.edu.co/index.php/saywa/article/view/674 https://repositorio.uan.edu.co/handle/123456789/11090 |
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