Toxinas animales ¿oportunidades farmacológicas frente a la isquemia cerebral?
Cerebrovascular diseases (CVD) comprise a group of disorders of the cerebral vasculature that decrease blood flow in the brain with temporary or permanent, generalized or focal involvement, with no apparent cause other than vascular origin. This review addresses a type of cerebrovascular accident -...
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UNIVERSIDAD ANTONIO NARIÑO
2022
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| Online Access: | https://revistas.uan.edu.co/index.php/saywa/article/view/1000 |
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| author | Bermúdez Urrego, Yair Santiago ReyesGuzmán, Edwin Alfredo Forero Vivas, María Elisa |
| author_facet | Bermúdez Urrego, Yair Santiago ReyesGuzmán, Edwin Alfredo Forero Vivas, María Elisa |
| author_sort | Bermúdez Urrego, Yair Santiago |
| collection | OJS |
| description | Cerebrovascular diseases (CVD) comprise a group of disorders of the cerebral vasculature that decrease blood flow in the brain with temporary or permanent, generalized or focal involvement, with no apparent cause other than vascular origin. This review addresses a type of cerebrovascular accident - ischemic (CVA) - which is defined as the death of an area of brain tissue as a consequence of an insufficient supply of blood and oxygen to the brain due to a blocked artery. Stroke is one of the main causes of death from chronic diseases around the world, and the second cause of death in Colombia (1). The objective is to present how peptide toxins of arachnid origin, specifically from the Phoneutria boliviensis species, could represent an alternative treatment thanks to their interesting potential in pharmacological development, since it is known that animal toxins act on specific receptors in the nervous system (SN). |
| format | Digital |
| id | revistas.uan.edu.co-article-1000 |
| institution | Revista SAYWA |
| language | spa |
| publishDate | 2022 |
| publisher | UNIVERSIDAD ANTONIO NARIÑO |
| record_format | ojs |
| spelling | revistas.uan.edu.co-article-10002022-10-13T18:07:02Z Animal toxins, pharmacological opportunities against brain ischemia? Toxinas animales ¿oportunidades farmacológicas frente a la isquemia cerebral? Bermúdez Urrego, Yair Santiago ReyesGuzmán, Edwin Alfredo Forero Vivas, María Elisa Isquemia Receptor NMDA Toxinas Citotoxicidad Tratamiento Excitotoxicidad Glutamato Farmacológico Cerebrovascular diseases (CVD) comprise a group of disorders of the cerebral vasculature that decrease blood flow in the brain with temporary or permanent, generalized or focal involvement, with no apparent cause other than vascular origin. This review addresses a type of cerebrovascular accident - ischemic (CVA) - which is defined as the death of an area of brain tissue as a consequence of an insufficient supply of blood and oxygen to the brain due to a blocked artery. Stroke is one of the main causes of death from chronic diseases around the world, and the second cause of death in Colombia (1). The objective is to present how peptide toxins of arachnid origin, specifically from the Phoneutria boliviensis species, could represent an alternative treatment thanks to their interesting potential in pharmacological development, since it is known that animal toxins act on specific receptors in the nervous system (SN). Las enfermedades cerebrovasculares (ECV) comprenden un conjunto de trastornos de la vasculatura cerebral que disminuyen el flujo sanguíneo en el cerebro con afectación transitoria o permanente, generalizada o focal, sin que exista otra causa aparente que el origen vascular. Esta revisión aborda un tipo de accidente cerebrovascular, -(ACV) isquémico- que se define como la muerte de una zona de tejido cerebral como consecuencia de un suministro insuficiente de sangre y oxígeno al cerebro debido a la obstrucción de una arteria. Siendo el ACV una de las principales causas de muerte por enfermedades crónicas alrededor del mundo, y la segunda causa de muerte en Colombia (1). El objetivo es presentar cómo unas toxinas peptídicas de origen arácnido, puntualmente de la especie Phoneutria boliviensis, podrían representar un tratamiento alternativo gracias a su interesante potencial en el desarrollo farmacológico, puesto que las toxinas animales actúan sobre receptores específicos en el sistema nervioso. UNIVERSIDAD ANTONIO NARIÑO 2022-10-13 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Divulgación científica application/pdf https://revistas.uan.edu.co/index.php/saywa/article/view/1000 REVISTA SAYWA; Vol. 3 Núm. 4 (2021); 33-40 2744-8576 2711-1571 spa https://revistas.uan.edu.co/index.php/saywa/article/view/1000/1113 Derechos de autor 2021 Yair Santiago Bermúdez Urrego, Edwin Alfredo ReyesGuzmán, María Elisa Forero Vivas https://creativecommons.org/licenses/by-nc-sa/4.0 |
| spellingShingle | Isquemia Receptor NMDA Toxinas Citotoxicidad Tratamiento Excitotoxicidad Glutamato Farmacológico Bermúdez Urrego, Yair Santiago ReyesGuzmán, Edwin Alfredo Forero Vivas, María Elisa Toxinas animales ¿oportunidades farmacológicas frente a la isquemia cerebral? |
| title | Toxinas animales ¿oportunidades farmacológicas frente a la isquemia cerebral? |
| title_alt | Animal toxins, pharmacological opportunities against brain ischemia? |
| title_full | Toxinas animales ¿oportunidades farmacológicas frente a la isquemia cerebral? |
| title_fullStr | Toxinas animales ¿oportunidades farmacológicas frente a la isquemia cerebral? |
| title_full_unstemmed | Toxinas animales ¿oportunidades farmacológicas frente a la isquemia cerebral? |
| title_short | Toxinas animales ¿oportunidades farmacológicas frente a la isquemia cerebral? |
| title_sort | toxinas animales oportunidades farmacologicas frente a la isquemia cerebral |
| topic | Isquemia Receptor NMDA Toxinas Citotoxicidad Tratamiento Excitotoxicidad Glutamato Farmacológico |
| topic_facet | Isquemia Receptor NMDA Toxinas Citotoxicidad Tratamiento Excitotoxicidad Glutamato Farmacológico |
| url | https://revistas.uan.edu.co/index.php/saywa/article/view/1000 |
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