Evaluación de controladores PID para el control de glucemia de pacientes con diabetes tipo 1 a partir de sincronizaciones mediante el método LAMBDA
In this degree work, an adjustment method called Lambda Tuning, widely used in PID control algorithms at an industrial level, was studied for the control of glycemia in patients with type 1 diabetes. Two controllers were implemented, a PID and a PD- basal, which were used for glycemic control of the...
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| Format: | Trabajo de grado (Pregrado y/o Especialización) |
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Universidad Antonio Nariño
2022
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| author | Gamez Peña, Yeferson Yovani |
| author2 | León Vargas, Fabian Mauricio |
| author_facet | León Vargas, Fabian Mauricio Gamez Peña, Yeferson Yovani |
| author_sort | Gamez Peña, Yeferson Yovani |
| collection | DSpace |
| description | In this degree work, an adjustment method called Lambda Tuning, widely used in PID
control algorithms at an industrial level, was studied for the control of glycemia in patients with
type 1 diabetes. Two controllers were implemented, a PID and a PD- basal, which were used for
glycemic control of the average adult patient with type 1 diabetes that is virtually included in the
Uva-Padova simulator, approved by the Food and Drug Administration (FDA) as a substitute for
conducting preclinical trials in animals.
For the application of the Lambda method, first order models plus dead time were
determined for the average adult patient of the Uva-Padova simulator in different operating
conditions (operating points). These models were used to adjust the PID and PD-basal controllers.
Finally, an evaluation of the performance of the controllers and of each control configuration was
carried out under different test conditions (scenario of one and three meals). The performance
obtained was analyzed according to metrics such as time in normoglycemia and percentage of time
in hypoglycemia.
It is expected that, thanks to the completion of this project, new adjustment alternatives for
PID controllers can be implemented in Artificial Pancreas systems. |
| format | Trabajo de grado (Pregrado y/o Especialización) |
| id | repositorio.uan.edu.co-123456789-7220 |
| institution | Repositorio Digital UAN |
| language | spa |
| publishDate | 2022 |
| publisher | Universidad Antonio Nariño |
| record_format | dspace |
| spelling | repositorio.uan.edu.co-123456789-72202024-10-09T23:28:40Z Evaluación de controladores PID para el control de glucemia de pacientes con diabetes tipo 1 a partir de sincronizaciones mediante el método LAMBDA Gamez Peña, Yeferson Yovani León Vargas, Fabian Mauricio Rodríguez Sarmiento, David Leonardo Lambda, PID, Glucemia, PD-basal, Uva-Padova. Lambda, PID, Glucemia, PD-basal, Uva-Padova. In this degree work, an adjustment method called Lambda Tuning, widely used in PID control algorithms at an industrial level, was studied for the control of glycemia in patients with type 1 diabetes. Two controllers were implemented, a PID and a PD- basal, which were used for glycemic control of the average adult patient with type 1 diabetes that is virtually included in the Uva-Padova simulator, approved by the Food and Drug Administration (FDA) as a substitute for conducting preclinical trials in animals. For the application of the Lambda method, first order models plus dead time were determined for the average adult patient of the Uva-Padova simulator in different operating conditions (operating points). These models were used to adjust the PID and PD-basal controllers. Finally, an evaluation of the performance of the controllers and of each control configuration was carried out under different test conditions (scenario of one and three meals). The performance obtained was analyzed according to metrics such as time in normoglycemia and percentage of time in hypoglycemia. It is expected that, thanks to the completion of this project, new adjustment alternatives for PID controllers can be implemented in Artificial Pancreas systems. En este trabajo de grado, se estudió un método de ajuste llamado Lambda Tuning, ampliamente utilizado en algoritmos de control PID a nivel industrial, para el control de glucemia de pacientes con diabetes tipo 1. Se implementaron dos controladores, un PID y un PD-basal, que fueron utilizados para el control de la glucemia del paciente adulto promedio con diabetes tipo 1 que se incluye virtualmente en el simulador Uva-Padova, aprobado por la Administración de Medicamentos y Alimentos (FDA) como sustituto para la realización de ensayos preclínicos en animales. Para la aplicación del método Lambda se determinaron modelos de primer orden más tiempo muerto, para el paciente adulto promedio del simulador Uva-Padova en distintas condiciones de operación (puntos de operación). Estos modelos fueron utilizados para el ajuste de los controladores PID y PD-basal. Finalmente se realizó una evaluación del desempeño de los controladores y de cada configuración de control sobre distintas condiciones de prueba (escenario de una y tres comidas). Se analizó el desempeño obtenido de acuerdo con métricas como tiempo en normoglucemia y porcentaje de tiempo en hipoglucemia. Se espera que, gracias a la realización de este proyecto, nuevas alternativas de ajuste de controladores PID puedan ser implementadas en sistemas de Páncreas Artificial. Ingeniero(a) en Control y Automatización Industrial Pregrado Presencial Investigación 2022-11-04T22:26:13Z 2022-11-04T22:26:13Z 2022-04-08 Trabajo de grado (Pregrado y/o Especialización) info:eu-repo/semantics/acceptedVersion http://purl.org/coar/resource_type/c_7a1f http://purl.org/coar/version/c_970fb48d4fbd8a85 http://repositorio.uan.edu.co/handle/123456789/7220 Bondia, J., Vehí, J., Palerm, C. C., & Herrero, P. (2010). El Ṕancreas Artificial: Control Autoḿatico de Infusíon de Insulina en Diabetes Mellitus Tipo 1. RIAI - Revista Iberoamericana de Automatica e Informatica Industrial. https://doi.org/10.4995/RIAI.2010.02.01 Colmegna, P., Sánchez-Peña, R. S., & Gondhalekar, R. (2018). Linear parameter-varying model to design control laws for an artificial pancreas. Biomedical Signal Processing and Control, 40, 208–213. https://doi.org/10.1016/J.BSPC.2017.09.021 Cooper, D. J. (2005). Practical Process Control using Loop-Pro Software. In Control Station, Inc. One Technology drive Dalla Man, C., Micheletto, F., Lv, D., Breton, M., Kovatchev, B., & Cobelli, C. (2014). The UVA/PADOVA Type 1 Diabetes Simulator: New Features. Journal of Diabetes Science and Technology, 8. https://doi.org/10.1177/1932296813514502 Danne, T., Nimri, R., Battelino, T., Bergenstal, R. M., Close, K. L., DeVries, J. H., Garg, S., Heinemann, L., Hirsch, I., Amiel, S. A., Beck, R., Bosi, E., Buckingham, B., Cobelli, C., Dassau, E., Doyle, F. J., Heller, S., Hovorka, R., Jia, W., … Phillip, M. (2017). International Consensus on Use of Continuous Glucose Monitoring. Diabetes Care, 40(12), 1631–1640. https://doi.org/10.2337/DC17- 1600 International Diabetes Federation. (2019). ATLAS DE LA DIABETES. Atlas de La Diabetes de La FID, 9, 1–180. https://diabetesatlas.org/es/ Karl Johan, Å., Tore, H., Kuo, B., Chen, C.-T., Paraskevopoulos, P. N., Paraskevopoulos, P. N., E.LeBlanc Steven, D. R. C., Goodwin, G. C., Graebe, S. F., Salgado, M. E., Morilla García, F., Rodríguez Rubio, F., Ortega Linares, M., Scharfstein, M., Gaurf, A, M. E. C. A. T. R. Ó. N. I. C., Walter, J., Dulhoste, J., Bomstein, Y., … Muños-Sánchez, Y. (2009). Control PID avanzado. In Modern Control Engineering (Vol. 23, Issue 4). PEARSON EDUACIÓN,S.A. León Vargas, F., Garelli, F., De Battista, H., & Vehí, J. (2013). Postprandial blood glucose control using a hybrid adaptive PD controller with insulin-on-board limitation. Biomedical Signal Processing and Control, 8. https://doi.org/10.1016/j.bspc.2013.06.008 Molano Jimenez, A., & León Vargas, F. (2017). Uva/Padova T1DMS dynamic model revision: For embedded model control. 2017 IEEE 3rd Colombian Conference on Automatic Control, CCAC 2017 - Conference Proceedings, 2018-Janua, 1–6. https://doi.org/10.1109/CCAC.2017.8276390 instname:Universidad Antonio Nariño reponame:Repositorio Institucional UAN repourl:https://repositorio.uan.edu.co/ spa Acceso abierto Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) https://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess http://purl.org/coar/access_right/c_abf2 application/pdf application/pdf application/pdf Colombia(Bogotá,Dc) Universidad Antonio Nariño Ingeniería en Control y Automatización Industrial Facultad de Ingeniería Mecánica, Electrónica y Biomédica Bogotá - Sur |
| spellingShingle | Lambda, PID, Glucemia, PD-basal, Uva-Padova. Lambda, PID, Glucemia, PD-basal, Uva-Padova. Gamez Peña, Yeferson Yovani Evaluación de controladores PID para el control de glucemia de pacientes con diabetes tipo 1 a partir de sincronizaciones mediante el método LAMBDA |
| title | Evaluación de controladores PID para el control de glucemia de pacientes con diabetes tipo 1 a partir de sincronizaciones mediante el método LAMBDA |
| title_full | Evaluación de controladores PID para el control de glucemia de pacientes con diabetes tipo 1 a partir de sincronizaciones mediante el método LAMBDA |
| title_fullStr | Evaluación de controladores PID para el control de glucemia de pacientes con diabetes tipo 1 a partir de sincronizaciones mediante el método LAMBDA |
| title_full_unstemmed | Evaluación de controladores PID para el control de glucemia de pacientes con diabetes tipo 1 a partir de sincronizaciones mediante el método LAMBDA |
| title_short | Evaluación de controladores PID para el control de glucemia de pacientes con diabetes tipo 1 a partir de sincronizaciones mediante el método LAMBDA |
| title_sort | evaluacion de controladores pid para el control de glucemia de pacientes con diabetes tipo 1 a partir de sincronizaciones mediante el metodo lambda |
| topic | Lambda, PID, Glucemia, PD-basal, Uva-Padova. Lambda, PID, Glucemia, PD-basal, Uva-Padova. |
| url | http://repositorio.uan.edu.co/handle/123456789/7220 |
| work_keys_str_mv | AT gamezpenayefersonyovani evaluaciondecontroladorespidparaelcontroldeglucemiadepacientescondiabetestipo1apartirdesincronizacionesmedianteelmetodolambda |
