“Mecanismos de acción de los receptores esteroideos que modulan la respuesta protectora en la esclerosis múltiple”.
The etiology of Multiple Sclerosis (MS) is complex and causes many changes and alterations at the level of the Central Nervous System (CNS), in addition, for a long time the prevalence of this disease has been increasing globally, with women being the most affected. Although multiple investigations...
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| Format: | Tesis y disertaciones (Maestría y/o Doctorado) |
| Language: | spa |
| Published: |
Universidad Antonio Nariño
2022
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| Online Access: | http://repositorio.uan.edu.co/handle/123456789/7177 |
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| Summary: | The etiology of Multiple Sclerosis (MS) is complex and causes many changes and alterations
at the level of the Central Nervous System (CNS), in addition, for a long time the prevalence
of this disease has been increasing globally, with women being the most affected. Although
multiple investigations have been carried out, multiple sclerosis is one of the diseases that
currently does not have an effective treatment and of the possible therapeutic alternatives that
exist, such as steroid hormones, the molecular mechanisms through which act. Therefore, it
is necessary to identify the mechanisms of action of the steroid receptors that have been
modulating the protective response in multiple sclerosis, through the review of the reported
literature that allowed characterizing the mechanisms of action of these steroid receptors
taking into account the sexual differences in the modulation of the protective response and
that are associated with the relief of the symptoms and the progression of the disease, in order
to have a perspective that allows targeted and selective treatments for this disease |
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