Tratamientos alternativos de origen natural para las enfermedades de Chagas y Leishmaniasis
The present work is a review of the state of the art on the antiparasitic potential of extracts and / or metabolites from plants, propolis and chitosan, as therapy for Leishmaniasis and Chagas disease. Products of natural origin capable of attacking the causative agents of these pathologies were ide...
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| Format: | Trabajo de grado (Pregrado y/o Especialización) |
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Universidad Antonio Nariño
2022
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| Online Access: | http://repositorio.uan.edu.co/handle/123456789/6379 |
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| author | Ramón González, Solangie |
| author2 | Bernal Rosas, Yuly Elien |
| author_facet | Bernal Rosas, Yuly Elien Ramón González, Solangie |
| author_sort | Ramón González, Solangie |
| collection | DSpace |
| description | The present work is a review of the state of the art on the antiparasitic potential of extracts and / or metabolites from plants, propolis and chitosan, as therapy for Leishmaniasis and Chagas disease. Products of natural origin capable of attacking the causative agents of these pathologies were identified Trypanosoma cruzi and Leishmania spp. Based on this, a study was proposed as an alternative in the treatment of these conditions. In order to develop this project, a descriptive literature review of the last six years (2015-2021) was carried out in the main scientific databases. The results do not describe relevant cellular toxicity, but they do describe high antiparasitic activity of plant extracts, propolis, chitosan and chitosan nanoparticles, which present various phytochemical compounds. These act directly on parasites or on host cells, activating immune response signaling pathways. |
| format | Trabajo de grado (Pregrado y/o Especialización) |
| id | repositorio.uan.edu.co-123456789-6379 |
| institution | Repositorio Digital UAN |
| language | spa |
| publishDate | 2022 |
| publisher | Universidad Antonio Nariño |
| record_format | dspace |
| spelling | repositorio.uan.edu.co-123456789-63792024-10-09T22:58:23Z Tratamientos alternativos de origen natural para las enfermedades de Chagas y Leishmaniasis Ramón González, Solangie Bernal Rosas, Yuly Elien Torres García, Orlando Alfredo Plantas Propóleo Quitosano Trypanosoma cruzi Leishmania spp 540 Plants Propolis Chitosan Trypanosoma cruzi Leishmania spp The present work is a review of the state of the art on the antiparasitic potential of extracts and / or metabolites from plants, propolis and chitosan, as therapy for Leishmaniasis and Chagas disease. Products of natural origin capable of attacking the causative agents of these pathologies were identified Trypanosoma cruzi and Leishmania spp. Based on this, a study was proposed as an alternative in the treatment of these conditions. In order to develop this project, a descriptive literature review of the last six years (2015-2021) was carried out in the main scientific databases. The results do not describe relevant cellular toxicity, but they do describe high antiparasitic activity of plant extracts, propolis, chitosan and chitosan nanoparticles, which present various phytochemical compounds. These act directly on parasites or on host cells, activating immune response signaling pathways. El presente trabajo es una revisión del estado del arte sobre el potencial antiparasitario de extractos y/o metabolitos provenientes de plantas, propóleos y quitosano, como terapia para Leishmaniasis y enfermedad de Chagas. Se identificaron productos de origen natural capaces de atacar los agentes causales de dichas patologías Trypanosoma cruzi y Leishmania spp. A partir de ello se planteó un estudio como alternativa en el tratamiento de estas afecciones. En aras de desarrollar este proyecto se realizó una revisión de literatura descriptiva de los últimos seis años (2015-2021), en las principales bases de datos científicas. Los resultados no describen toxicidad celular relevante, pero sí alta actividad antiparasitaria de extractos vegetales, propóleos, quitosano y nanopartículas de quitosano, que presentan diversos compuestos fitoquímicos. Estos ejercen acción directamente en los parásitos o en las células del huésped, activando vías de señalización de respuesta inmune. Bioquímico(a) Pregrado Presencial Monografía 2022-04-30T14:42:28Z 2022-04-30T14:42:28Z 2021-11-25 Trabajo de grado (Pregrado y/o Especialización) info:eu-repo/semantics/acceptedVersion http://purl.org/coar/resource_type/c_7a1f http://purl.org/coar/version/c_970fb48d4fbd8a85 http://repositorio.uan.edu.co/handle/123456789/6379 Abadías-Granado I., Diago, A., Cerro, P. A., Palma-Ruiz, A.M., & Gilaberte, Y. (2021). Cutaneous and mucocutaneous leishmaniasis. Actas Dermo-Sifiliograficas. https://doi.org/10.1016/j.ad.2021.02.008 Akhoundi, M., Kuhls, K., Cannet, A., Votypka, J., Marty, P., Delaunay, P., & Sereno, D. (2016). A historical overview of the classification, evolution and dispersion of leishmania parasites and sandflies. PLoS Neglected Tropical Diseases, 10(3), e0004349. https://doi.org/10.1371/journal.pntd.0004349 Aksoy, T., Sivcan, E., Dogan, F., Cetin, S., & Yar, T. M. (2020). (Investigation of Anti-Leishmanial Effects of Bee Products (Honey Propolis), on Leishmania Tropica Promastigotes). Mikrobyoloji Bulteni, 54(3) 479-489. https://doi.org/10.5578/mb.69632 Alotaibi, Abdullah, Ebiloma, G. U., Williams, R., Alenezi, S., Donachie, A. M., Guillaume, S., Igoli, J. O., Fearnley, J., de Koning, H. P., & Watson, D. G. (2019). European propolis is highly active against trypanosomatids including Crithidia fasciculata. Scientific Reports, 9(1), 11364. https://doi.org/10.1038/s41598-019-47840-y Alotaibi, Abdullah, Ebiloma, G. U., Williams, R., Alfayez, I. A., Natto, M. J., Alenezi, S., Siheri, W., AlQarni, M., Igoli, J. O., Fearnley, J., de Koning, H. P., & Watson, D. G. (2021). Activity of Compounds from Temperate Propolis against Trypanosoma brucei and Leishmania mexicana. Molecules (Basel Switzerland), 26(13). https://doi.org/10.3390/molecules26133912 Alves, D. R., Maia de Morais, S., Tomiotto-Pellissier, F., Miranda-Sapla, M. M., Vasconcelos, F, R., da Silva, I. N. G., Araujo de Sousa, H., Assolini, J. P., Conchon-Costa, I., Pavanelli, W. R., & Freire, F. das C. O. (2017). Flavonoid Composition and Biological Activities of Ethanol Extracts of Caryocar coriaceum Wittm., a Native Plant from Caatinga biome. Evidence-Based Complementary and Alternative Medicine, 2017, 6834218. https://doi.org/10.1155/2017/6834218 Andrade, M. A., Azevedo, C. D. S., Motta, F. N., Santos, M. L. D., Silva, C. L., Santana, J. M., de & Bastos, I. M. D. (2016). Essentials oils: in vitro activity against Leishmania amazonensis, cytotoxity and chemical composition. BMC Complementary and Alternative Medicine, 16(1), 444. https://doi.org/10.1186/s12906-016-1401-9 Aquino, A. B., de, Cavalcante-Silva, L. H. A., Matta, C, B. B., da, Epifanio, W. A. do N., Aquino, P. G. V., Santana, A. E. G., Alexandre-Moreira, M. S., & de Araújo-Júnior, J. X. (2013). The antinociceptive and anti-inflammatory activities of Aspidosperma tomentosum (Apocynaceae). Thescientificworldjournal, 2013, 218627. https://doi.org/10.1155/2013/218627 Arias-Giraldo, L. M., Muñoz, M., Hernández, C., Herrera, G., Velásquez-Ortiz, N., Cantillo-Barraza, O., Urbano, P., & Ramírez, J. D. (2020). Species-dependent variation of the gut bacterial communities across Trypanosoma cruzi insect vectors. Plos One 15(11), e0240916. https://doi.org/10.1371/journal.pone.0240916 Arrúa, E. C., Seremeta, K. P., Bedogni, G. R., Okulik., N. B., & Salomon, C. J. (2019). Nanocarriers for effective delivery of benznidazole and nifurtimux in the treatment of chagas disease. A review. Acta Tropica, 198. 105080. https://doi.org/10.1016/j.actatropica.2019.105080 instname:Universidad Antonio Nariño reponame:Repositorio Institucional UAN repourl:https://repositorio.uan.edu.co/ spa Acceso abierto Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) https://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess http://purl.org/coar/access_right/c_abf2 application/pdf application/pdf application/pdf Universidad Antonio Nariño Bioquímica Facultad de Ciencias Bogotá - Circunvalar |
| spellingShingle | Plantas Propóleo Quitosano Trypanosoma cruzi Leishmania spp 540 Plants Propolis Chitosan Trypanosoma cruzi Leishmania spp Ramón González, Solangie Tratamientos alternativos de origen natural para las enfermedades de Chagas y Leishmaniasis |
| title | Tratamientos alternativos de origen natural para las enfermedades de Chagas y Leishmaniasis |
| title_full | Tratamientos alternativos de origen natural para las enfermedades de Chagas y Leishmaniasis |
| title_fullStr | Tratamientos alternativos de origen natural para las enfermedades de Chagas y Leishmaniasis |
| title_full_unstemmed | Tratamientos alternativos de origen natural para las enfermedades de Chagas y Leishmaniasis |
| title_short | Tratamientos alternativos de origen natural para las enfermedades de Chagas y Leishmaniasis |
| title_sort | tratamientos alternativos de origen natural para las enfermedades de chagas y leishmaniasis |
| topic | Plantas Propóleo Quitosano Trypanosoma cruzi Leishmania spp 540 Plants Propolis Chitosan Trypanosoma cruzi Leishmania spp |
| url | http://repositorio.uan.edu.co/handle/123456789/6379 |
| work_keys_str_mv | AT ramongonzalezsolangie tratamientosalternativosdeorigennaturalparalasenfermedadesdechagasyleishmaniasis |
