Uso de biomarcadores en el cáncer de cavidad oral
Cancer is the result of the uncontrolled proliferation of abnormal cells, either caused by genetic (molecular) changes that are transmitted from the parents to their children (hereditary) or that occur in the body throughout the life of a person (acquired). Each type of cancer has a unique group of...
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Universidad Antonio Nariño
2021
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| Online Access: | http://repositorio.uan.edu.co/handle/123456789/5046 |
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| author | Ibarra Díaz, Karen Julieth Fajardo López, Lizeth Sarmiento, Keila |
| author2 | García Florez, Manuel |
| author_facet | García Florez, Manuel Ibarra Díaz, Karen Julieth Fajardo López, Lizeth Sarmiento, Keila |
| author_sort | Ibarra Díaz, Karen Julieth |
| collection | DSpace |
| description | Cancer is the result of the uncontrolled proliferation of abnormal cells,
either caused by genetic (molecular) changes that are transmitted from the
parents to their children (hereditary) or that occur in the body throughout the
life of a person (acquired). Each type of cancer has a unique group of
molecular changes in cancer cells. Technological advances have
made molecular testing possible, allowing clinicians to identify
the molecular differences between cancer cells and healthy cells.
The development of this work aims to propose and develop a study
on a marker (or pool of markers) that allows a diagnosis
precise state of the pathology and if it is easily obtained through
minimally invasive methods, we would be facing an ideal marker that would contribute to
timely treatment promoting the quality of life of patients,
we will talk about microRNAs, which are small RNAs that regulate the expression
of your target genes through decreased expression of proteins
encoded by these genes, by repression of translation and / or degradation
of its mRNA. MiRNAs play a fundamental role in virtually all
cellular processes including development, function and survival. miRNAs are
as critical regulators of immune tolerance and autoimmunity,
These are as potential new therapeutic targets for the treatment of
multiple diseases. |
| format | Trabajo de grado (Pregrado y/o Especialización) |
| id | repositorio.uan.edu.co-123456789-5046 |
| institution | Repositorio Digital UAN |
| language | spa |
| publishDate | 2021 |
| publisher | Universidad Antonio Nariño |
| record_format | dspace |
| spelling | repositorio.uan.edu.co-123456789-50462024-10-09T23:23:06Z Uso de biomarcadores en el cáncer de cavidad oral Ibarra Díaz, Karen Julieth Fajardo López, Lizeth Sarmiento, Keila García Florez, Manuel Lesión Bucal ARN de pequeño tamaño Oral Injury Small RNA Cancer is the result of the uncontrolled proliferation of abnormal cells, either caused by genetic (molecular) changes that are transmitted from the parents to their children (hereditary) or that occur in the body throughout the life of a person (acquired). Each type of cancer has a unique group of molecular changes in cancer cells. Technological advances have made molecular testing possible, allowing clinicians to identify the molecular differences between cancer cells and healthy cells. The development of this work aims to propose and develop a study on a marker (or pool of markers) that allows a diagnosis precise state of the pathology and if it is easily obtained through minimally invasive methods, we would be facing an ideal marker that would contribute to timely treatment promoting the quality of life of patients, we will talk about microRNAs, which are small RNAs that regulate the expression of your target genes through decreased expression of proteins encoded by these genes, by repression of translation and / or degradation of its mRNA. MiRNAs play a fundamental role in virtually all cellular processes including development, function and survival. miRNAs are as critical regulators of immune tolerance and autoimmunity, These are as potential new therapeutic targets for the treatment of multiple diseases. El cáncer es el resultado de la proliferación descontrolada de células anormales, ya sea provocada por cambios genéticos (moleculares) que se transmiten de los padres a sus hijos (hereditarios) o que se presentan en el cuerpo a lo largo de la vida de una persona (adquiridos). Cada tipo de cáncer presenta un grupo único de cambios moleculares en las células cancerosas. Los avances tecnológicos han hecho posible las pruebas moleculares, lo cual permite a los médicos identificar las diferencias moleculares entre las células cancerosas y las células sanas. El desarrollo de este trabajo tiene como finalidad proponer y desarrollar un estudio sobre un marcador (o pool de marcadores) que permita tener un diagnóstico preciso del estado de la patología y si este es de fácil obtención a través de métodos poco invasivos, estaríamos ante un marcador ideal que contribuiría con un tratamiento a tiempo promoviendo la calidad de vida de los pacientes, hablaremos de los microRNA que son pequeños ARNs que regulan la expresión de sus genes diana a través de la disminución de expresión de las proteínas codificadas por dichos genes, mediante represión de la traducción y/o degradación de su ARNm. Los miRNAs juegan un papel fundamental en virtualmente todos los procesos celulares incluyendo desarrollo, función y supervivencia. los miRNAs son como reguladores críticos de la tolerancia inmunológica y de la autoinmunidad, estos son como potenciales nuevas dianas terapéuticas para el tratamiento de múltiples enfermedades. Odontólogo(a) Pregrado Presencial Investigación 2021-10-14T21:24:12Z 2021-10-14T21:24:12Z 2021-05-20 Trabajo de grado (Pregrado y/o Especialización) info:eu-repo/semantics/acceptedVersion http://purl.org/coar/resource_type/c_7a1f http://purl.org/coar/version/c_970fb48d4fbd8a85 http://repositorio.uan.edu.co/handle/123456789/5046 Calin GA, Dumitru CD, Shimizu M, Bichi R, Zupo S, Noch E, et al. Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A. 2002;99(24):15524-9. Croce C. Introduction to the role of microRNAs in cancer diagnosis, prognosis, and treatment. Cancer J. 2012;18(3):213-4. Edge SB, Compton CC. The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol. 2010;17(6):1471-4. instname:Universidad Antonio Nariño reponame:Repositorio Institucional UAN repourl:https://repositorio.uan.edu.co/ spa Acceso abierto Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) https://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess http://purl.org/coar/access_right/c_abf2 application/pdf application/pdf application/pdf application/pdf application/pdf Huila (Colombia) Universidad Antonio Nariño Odontología Facultad de Odontología Neiva Buganviles |
| spellingShingle | Lesión Bucal ARN de pequeño tamaño Oral Injury Small RNA Ibarra Díaz, Karen Julieth Fajardo López, Lizeth Sarmiento, Keila Uso de biomarcadores en el cáncer de cavidad oral |
| title | Uso de biomarcadores en el cáncer de cavidad oral |
| title_full | Uso de biomarcadores en el cáncer de cavidad oral |
| title_fullStr | Uso de biomarcadores en el cáncer de cavidad oral |
| title_full_unstemmed | Uso de biomarcadores en el cáncer de cavidad oral |
| title_short | Uso de biomarcadores en el cáncer de cavidad oral |
| title_sort | uso de biomarcadores en el cancer de cavidad oral |
| topic | Lesión Bucal ARN de pequeño tamaño Oral Injury Small RNA |
| url | http://repositorio.uan.edu.co/handle/123456789/5046 |
| work_keys_str_mv | AT ibarradiazkarenjulieth usodebiomarcadoresenelcancerdecavidadoral AT fajardolopezlizeth usodebiomarcadoresenelcancerdecavidadoral AT sarmientokeila usodebiomarcadoresenelcancerdecavidadoral |
