Protein fibrillation: the good, the bad and the ugly
Protein fibrillation is a process in which the peptide chains are slightly modified form native structure to yield fibers. The mechanism that leads to this fiber conformations is little known. An accepted hypothesis is the “entropic cone”, according to this hypothesis a pre-unfolded structure plays...
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| Format: | Divulgación científica |
| Language: | spa |
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Universidad Antonio Nariño
2021
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| Online Access: | http://revistas.uan.edu.co/index.php/saywa/article/view/674 http://repositorio.uan.edu.co/handle/123456789/4438 |
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| author | Segura, Karen Malagón, Edwin Andres |
| author_facet | Segura, Karen Malagón, Edwin Andres |
| author_sort | Segura, Karen |
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| description | Protein fibrillation is a process in which the peptide chains are slightly modified form native structure to yield fibers. The mechanism that leads to this fiber conformations is little known. An accepted hypothesis is the “entropic cone”, according to this hypothesis a pre-unfolded structure plays a crucial role in the fiber growth. Fibrillation can offer certain advantages, since the new structure offers technological possibilities. On the other hand, when the process occurs inside tissues could be responsible to generate a series of illness known as “amyloidosis”. At the University Antonio Nariño a family of macrocyclic molecules, the resorcinarenes, is been studied. Preliminary results indicate that thismacrocycles are able to inhibit the fibrillation of certain proteins. |
| format | Divulgación científica |
| id | repositorio.uan.edu.co-123456789-4438 |
| institution | Repositorio Digital UAN |
| language | spa |
| publishDate | 2021 |
| publisher | Universidad Antonio Nariño |
| record_format | dspace |
| spelling | repositorio.uan.edu.co-123456789-44382024-10-09T22:43:50Z Protein fibrillation: the good, the bad and the ugly Fibrilación de proteínas: Lo bueno, lo malo y lo feo Segura, Karen Malagón, Edwin Andres Protein fibrillation is a process in which the peptide chains are slightly modified form native structure to yield fibers. The mechanism that leads to this fiber conformations is little known. An accepted hypothesis is the “entropic cone”, according to this hypothesis a pre-unfolded structure plays a crucial role in the fiber growth. Fibrillation can offer certain advantages, since the new structure offers technological possibilities. On the other hand, when the process occurs inside tissues could be responsible to generate a series of illness known as “amyloidosis”. At the University Antonio Nariño a family of macrocyclic molecules, the resorcinarenes, is been studied. Preliminary results indicate that thismacrocycles are able to inhibit the fibrillation of certain proteins. Los procesos de fibrilación de proteínas se refieren a la unión de cadenas ligeramente modificadas en su estructura nativa, formando pequeñas fibras. Se conoce poco acerca del mecanismo que conduce a estas conformaciones, una hipótesis difundida y aceptada es la del cono entrópico, según la cual una estructura pre-desplegada es crucial en el crecimiento de fibras. La fibrilación puede presentar ventajas en cuanto a que las proteínas así conformadas tienen cualidades aprovechables tecnológicamente. Por otra parte, si el proceso ocurre en tejidos podría generar enfermedades conocidas como amiloidosis. En la Universidad Antonio Nariño se han estudiado moléculas macrocíclicas tipo resorcinareno capaces de inhibir la fibrilación de algunas proteínas. 2021-06-16T13:59:56Z 2021-06-16T13:59:56Z 2020-03-20 Divulgación científica info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_2df8fbb1 info:eu-repo/semantics/article http://purl.org/coar/version/c_970fb48d4fbd8a85 http://revistas.uan.edu.co/index.php/saywa/article/view/674 http://repositorio.uan.edu.co/handle/123456789/4438 spa http://revistas.uan.edu.co/index.php/saywa/article/view/674/574 Acceso abierto Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) https://creativecommons.org/licenses/by-nc-sa/4.0/ info:eu-repo/semantics/openAccess http://purl.org/coar/access_right/c_abf2 application/pdf Universidad Antonio Nariño 2711-1571 REVISTA SAYWA; Vol. 1 Núm. 1 (2019) |
| spellingShingle | Segura, Karen Malagón, Edwin Andres Protein fibrillation: the good, the bad and the ugly |
| title | Protein fibrillation: the good, the bad and the ugly |
| title_full | Protein fibrillation: the good, the bad and the ugly |
| title_fullStr | Protein fibrillation: the good, the bad and the ugly |
| title_full_unstemmed | Protein fibrillation: the good, the bad and the ugly |
| title_short | Protein fibrillation: the good, the bad and the ugly |
| title_sort | protein fibrillation the good the bad and the ugly |
| url | http://revistas.uan.edu.co/index.php/saywa/article/view/674 http://repositorio.uan.edu.co/handle/123456789/4438 |
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