Analisis De Longitud Telomérica En Pacientes Con Demencia Tipo Alzheimer En Colombia
Alzheimer's disease, a neurodegenerative disorder that mainly affects older people, has been linked to alterations in telomeric length, a structure that protects chromosomes. However, in Colombia, studies on telomeric length in the context of this disease are limited, since most research focuse...
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| Formato: | Tesis/Trabajo de grado - Monografía - Pregrado |
| Lenguaje: | Español |
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Universidad Antonio Nariño
2025
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| Acceso en línea: | https://repositorio.uan.edu.co/handle/123456789/12198 |
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| _version_ | 1831063260633235456 |
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| author | Arias Ovalle, Juan Andrés |
| author2 | Trujillo Güiza, Martha Liliana |
| author_facet | Trujillo Güiza, Martha Liliana Arias Ovalle, Juan Andrés |
| author_sort | Arias Ovalle, Juan Andrés |
| collection | DSpace |
| description | Alzheimer's disease, a neurodegenerative disorder that mainly affects older people,
has been linked to alterations in telomeric length, a structure that protects chromosomes.
However, in Colombia, studies on telomeric length in the context of this disease are
limited, since most research focuses on specific mutations. This work aimed to analyze the
relationship between telomeric length and Alzheimer's disease in a sample of Colombian
patients. We collected 39 peripheral blood samples from patients diagnosed with
Alzheimer's disease and a control group, also evaluating factors such as age and gender of
the participants. T |
| format | Tesis/Trabajo de grado - Monografía - Pregrado |
| id | repositorio.uan.edu.co-123456789-12198 |
| institution | Repositorio Digital UAN |
| language | Español |
| publishDate | 2025 |
| publisher | Universidad Antonio Nariño |
| record_format | dspace |
| spelling | repositorio.uan.edu.co-123456789-121982025-02-04T21:17:30Z Analisis De Longitud Telomérica En Pacientes Con Demencia Tipo Alzheimer En Colombia Arias Ovalle, Juan Andrés Trujillo Güiza, Martha Liliana González Giraldo, Yeimy Longitud telomérica Enfermedad de Alzheimer Telómeros Pacientes Colombia Telomere length Alzheimer's disease Telomeres Patients Colombia MMQPCR Alzheimer's disease, a neurodegenerative disorder that mainly affects older people, has been linked to alterations in telomeric length, a structure that protects chromosomes. However, in Colombia, studies on telomeric length in the context of this disease are limited, since most research focuses on specific mutations. This work aimed to analyze the relationship between telomeric length and Alzheimer's disease in a sample of Colombian patients. We collected 39 peripheral blood samples from patients diagnosed with Alzheimer's disease and a control group, also evaluating factors such as age and gender of the participants. T La enfermedad de Alzheimer, un trastorno neurodegenerativo que afecta principalmente a personas mayores, se ha relacionado con alteraciones en la longitud telomérica, una estructura que protege los cromosomas. Sin embargo, en Colombia, los estudios sobre la longitud telomérica en el contexto de esta enfermedad son limitados, ya que la mayoría de las investigaciones se centran en mutaciones específicas. Este trabajo tuvo como objetivo analizar la relación entre la longitud telomérica y la enfermedad de Alzheimer en una muestra de pacientes colombianos. final Bioquímico(a) Pregrado Presencial Investigación 2025-02-04T21:17:29Z 2025-02-04T21:17:29Z 2024-11-30 2025-02-04 Tesis/Trabajo de grado - Monografía - Pregrado Estudio descriptivo info:eu-repo/semantics/draft http://purl.org/coar/resource_type/c_46ec http://purl.org/redcol/resource_type/PIC http://purl.org/coar/version/c_b1a7d7d4d402bcce https://repositorio.uan.edu.co/handle/123456789/12198 Español info:eu-repo/semantics/restrictedAccess http://purl.org/coar/access_right/c_16ec pdf application/pdf application/pdf application/pdf Universidad Antonio Nariño Bioquímica Facultad de Ciencias Bogotá - Circunvalar instname:Universidad Antonio Nariño Albert, M. S., DeKosky, S. T., Dickson, D., Dubois, B., Feldman, H. H., Fox, N. C., Gamst, A., Holtzman, D. M., Jagust, W. J., Petersen, R. C., Snyder, P. J., Carrillo, M. C., Thies, B., & Phelps, C. H. (2011). The diagnosis of mild cognitive impairment due to Alzheimer's disease recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association, 7(3), 270–279. https://doi.org/10.1016/j.jalz.2011.03.008 Anitha, A., Thanseem, I., Vasu, M. M., Viswambharan, V., & Poovathinal, S. A. (2019). Telomeres in neurological disorders. Advances in clinical chemistry, 90, 81–132. https://www.doi.org/10.1016/BS.ACC.2019.01.003 Blennow, K., & Zetterberg, H. (2022). The Neurochemistry of Alzheimer’s Disease: One of the Most Common Causes of Reduced Capability in the Adult Population. In: Falk Erhag, H., Lagerlöf Nilsson, U., Rydberg Sterner, T., Skoog, I. (eds) A Multidisciplinary Approach to Capability in Age and Age. Springer, 31, 81–93. https://www.doi.org/10.1007/978-3-030-78063-0_7 Caleb, V., Kyle, S., Dennis, M., Darcy, W., Jerome, C., Sidhartha D., R., & Siyaram, P. (2019). A Bird’s-Eye View of the Multiple Biochemical Mechanisms That Propel Pathology of Alzheimer’s Disease: Recent Advances and Mechanistic Perspectives on How to Halt the Disease Progression Targeting Multiple Pathways. Journal of Alzheimer's Disease, 69(3), 631-649. https://www.doi.org/10.3233/JAD-181230 Cawthon, R. M. (2009). Telomere length measurement by a novel monochrome multiplex quantitative PCR method. Nucleic Acids Research, 37(3), e21. https://doi.org/10.1093/nar/gkn1027 Chatterjee, & Shailja. (2017). Telomeres in health and disease. Journal of Oral and Maxillofacial Pathology, 21(1), 87-91. https://doi.org/10.4103/jomfp.JOMFP_39_16 Cusanelli, E., & Chartrand, P. (2014). Telomeric noncoding RNA: telomeric repeat-containing RNA in telomere biology. Wiley interdisciplinary reviews. RNA, 5(3), 407–419. https://doi.org/10.1002/wrna.1220 Dalgård, C., Benetos, A., Verhulst, S., Labat, C., Kark, J. D., Christensen, K., Kimura, M., Kyvik, K. O., & Aviv, A. (2015). Leukocyte telomere length dynamics in women and men: menopause vs age effects. International Journal of Epidemiology, 44(5), 1688–1695. https://doi.org/10.1093/ije/dyv165 Dementia. (2023, marzo 15). World Health Organization (WHO). https://www.who.int/news-room/fact-sheets/detail/dementia Farooqui, A. A. (2016). Neurochemical Aspects of Alzheimer Disease. In: Therapeutic Potentials of Curcumin for Alzheimer Disease. Springer, 1-76. https://doi.org/10.1007/978-3-319-15889-1_1 |
| spellingShingle | Longitud telomérica Enfermedad de Alzheimer Telómeros Pacientes Colombia Telomere length Alzheimer's disease Telomeres Patients Colombia MMQPCR Arias Ovalle, Juan Andrés Analisis De Longitud Telomérica En Pacientes Con Demencia Tipo Alzheimer En Colombia |
| title | Analisis De Longitud Telomérica En Pacientes Con Demencia Tipo Alzheimer En Colombia |
| title_full | Analisis De Longitud Telomérica En Pacientes Con Demencia Tipo Alzheimer En Colombia |
| title_fullStr | Analisis De Longitud Telomérica En Pacientes Con Demencia Tipo Alzheimer En Colombia |
| title_full_unstemmed | Analisis De Longitud Telomérica En Pacientes Con Demencia Tipo Alzheimer En Colombia |
| title_short | Analisis De Longitud Telomérica En Pacientes Con Demencia Tipo Alzheimer En Colombia |
| title_sort | analisis de longitud telomerica en pacientes con demencia tipo alzheimer en colombia |
| topic | Longitud telomérica Enfermedad de Alzheimer Telómeros Pacientes Colombia Telomere length Alzheimer's disease Telomeres Patients Colombia MMQPCR |
| url | https://repositorio.uan.edu.co/handle/123456789/12198 |
| work_keys_str_mv | AT ariasovallejuanandres analisisdelongitudtelomericaenpacientescondemenciatipoalzheimerencolombia |
