Explorando la interacción bioquímica entre NMDAR, Esquizofrenia infantil y Grinpatias : “Implicaciones para la claridad diagnóstica”

N-methyl D-aspartate receptors are ligand-activated ionotropic receptors that mediate a slow, calcium-permeable component of excitatory activity, which is important in synaptic transmission in the CNS. Variants in genes that encode subunits NMDARs have been associated with a spectrum of neurodevelop...

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Bibliographic Details
Main Author:	Cerón Gutiérrez, Andrés Felipe
Other Authors:	Báez Jurado, Eliana María
Format:	Tesis/Trabajo de grado - Monografía - Pregrado
Language:	Español
Published:	Universidad Antonio Nariño 2025
Subjects:	NMDAR gen GRIN encefalopatía infantil esquizofrenia Glun1 GRIN gen Pediatric encephalopathy SNC schizophrenia
Online Access:	https://repositorio.uan.edu.co/handle/123456789/12197
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Summary:	N-methyl D-aspartate receptors are ligand-activated ionotropic receptors that mediate a slow, calcium-permeable component of excitatory activity, which is important in synaptic transmission in the CNS. Variants in genes that encode subunits NMDARs have been associated with a spectrum of neurodevelopmental disorders; these disorders include Alzheimer's disease, Huntington's disease, depression, schizophrenia, stroke, traumatic brain injury, and epilepsy. (Benke, T. A 2021) These disorders are known as GRINpathies given their name to the GRIN genes, which when altered manifest a dysfunction in the NMDAR receptor mechanism.