Estudio del papel de la Laminina Beta 1 en células endoteliales de la barrera hematoencefálica (hCMEC/D3) bajo condiciones inflamatorias
The blood-brain barrier is crucial for protecting the central nervous system, and its dysfunction is associated with various neurological diseases. The present study investigates the role of laminin beta 1 in blood-brain barrier integrity and its influence on cell viability using a model of human mi...
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| Language: | Español |
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Universidad Antonio Nariño
2025
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| author | González Bonilla, Emily Vanessa Losada Barragán, Mónica Vargas Sánchez, Karina |
| author2 | Losada Barragán , Mónica |
| author_facet | Losada Barragán , Mónica González Bonilla, Emily Vanessa Losada Barragán, Mónica Vargas Sánchez, Karina |
| author_sort | González Bonilla, Emily Vanessa |
| collection | DSpace |
| description | The blood-brain barrier is crucial for protecting the central nervous system, and its dysfunction is
associated with various neurological diseases. The present study investigates the role of laminin beta
1 in blood-brain barrier integrity and its influence on cell viability using a model of human
microvascular endothelial cells exposed to interleukin 1 beta-induced inflammation. |
| format | Tesis/Trabajo de grado - Monografía - Pregrado |
| id | repositorio.uan.edu.co-123456789-12193 |
| institution | Repositorio Digital UAN |
| language | Español |
| publishDate | 2025 |
| publisher | Universidad Antonio Nariño |
| record_format | dspace |
| spelling | repositorio.uan.edu.co-123456789-121932025-02-04T19:38:17Z Estudio del papel de la Laminina Beta 1 en células endoteliales de la barrera hematoencefálica (hCMEC/D3) bajo condiciones inflamatorias González Bonilla, Emily Vanessa Losada Barragán, Mónica Vargas Sánchez, Karina Losada Barragán , Mónica Vargas Sánchez , Karina Barrera hematoencefálica Uniones estrechas Matriz extracelular Inflamación Laminina blood-brain barrier tight junctions extracellular matrix inflammation laminin The blood-brain barrier is crucial for protecting the central nervous system, and its dysfunction is associated with various neurological diseases. The present study investigates the role of laminin beta 1 in blood-brain barrier integrity and its influence on cell viability using a model of human microvascular endothelial cells exposed to interleukin 1 beta-induced inflammation. La barrera hematoencefálica es crucial para proteger el sistema nervioso central, y su disfunción está relacionada con diversas enfermedades neurológicas. El presente estudio investiga el papel de la laminina beta 1 en la integridad de la barrera hematoencefálica y su influencia en la viabilidad celular, utilizando un modelo de células endoteliales microvasculares humanas expuestas a inflamación inducida por interleucina 1 beta. final Bioquímico(a) Pregrado Presencial Investigación 2025-02-04T19:38:15Z 2025-02-04T19:38:15Z 2024-11-30 2025-02-03 Tesis/Trabajo de grado - Monografía - Pregrado Estudio descriptivo info:eu-repo/semantics/draft http://purl.org/coar/resource_type/c_46ec http://purl.org/redcol/resource_type/PIC http://purl.org/coar/version/c_b1a7d7d4d402bcce https://repositorio.uan.edu.co/handle/123456789/12193 Español info:eu-repo/semantics/restrictedAccess http://purl.org/coar/access_right/c_16ec pdf application/pdf application/pdf application/pdf Universidad Antonio Nariño Bioquímica Facultad de Ciencias Bogotá - Circunvalar instname:Universidad Antonio Nariño Abbott, N.J., Patabendige, A. A.K., Dolman, D. E.M., Yusof, S. R., & Begley, D. J. (2010, January). Structure and function of the blood–brain barrier. Neurobiology of Disease, 37(1), 13-25. https://doi.org/10.1016/j.nbd.2009.07.030 Adelman, K., Kennedy, M. A., Nechaev, S., Gilchrist, D. A., Muse, G. W., Chinenov, Y., & Rogatsky, I. (2009). Immediate mediators of the inflammatory response are poised for gene activation through RNA polymerase II stalling. Proceedings of the National Academy of Sciences of the United States of America. https://doi.org/10.1073/pnas.0910177106 Alahmari, A. (2021). Blood-Brain Barrier Overview: Structural and Functional Correlation. Neural Plasticity. https://doi.org/10.1155/2021/6564585 Baeten, K. M., & Akassoglou, K. (2011). Extracellular Matrix and Matrix Receptors in Blood-Brain Barrier Formation and Stroke. Developmental Neurobiology. https://doi.org/10.1002/dneu.20954 Berselli, A., Alberini, G., Benfenati, F., & Maragliano, L. (2022). Computational Assessment of Different Structural Models for Claudin-5 Complexes in Blood-Brain Barrier Tight Junctions. ACS Chemical Neuroscience. https://doi.org/10.1021/acschemneuro.2c00139 Bhat, A. A., Haris, M., Macha, M. A., & Dhawan, P. (Eds.). (2023). Tight Junctions in Inflammation and Cancer. Springer Nature Singapore. https://doi.org/10.1007/978-981-99-2415-8_6 Chean Lim, W., Olding, M., Healy, E., & Millar, T. M. (2018). Human Endothelial Cells Modulate CD4+ T Cell Populations and Enhance Regulatory T Cell Suppressive Capacity. Frontiers in immunology, 23(9). https://doi.org/10.3389/fimmu.2018.00565 Chen, L., Deng, H., Cui, H., Fang, J., Zuo, Z., Deng, J., Li, Y., Wang, X., & Zhao, L. (2017). Inflammatory responses and inflammation-associated diseases in organs. Oncotarget, 9(6), 7204–7218. https://doi.org/10.18632/oncotarget.23208 Chen, T., Dai, Y., Hu, C., Lin, Z., Wang, S., Yang, J., Zeng, L., Li, S., & Li, W. (2024). Cellular and molecular mechanisms of the blood–brain barrier dysfunction in neurodegenerative diseases. Fluids Barriers CNS. https://doi.org/10.1186/s12987-024-00557-1 Dahm, T., Rudolph, H., Schwerk, C., Schroten, H., & Tenenbaum, T. (2016). Neuroinvasion and Inflammation in Viral Central Nervous System Infections. Mediators of Inflammation. https://doi.org/10.1155/2016/8562805 |
| spellingShingle | Barrera hematoencefálica Uniones estrechas Matriz extracelular Inflamación Laminina blood-brain barrier tight junctions extracellular matrix inflammation laminin González Bonilla, Emily Vanessa Losada Barragán, Mónica Vargas Sánchez, Karina Estudio del papel de la Laminina Beta 1 en células endoteliales de la barrera hematoencefálica (hCMEC/D3) bajo condiciones inflamatorias |
| title | Estudio del papel de la Laminina Beta 1 en células endoteliales de la barrera hematoencefálica (hCMEC/D3) bajo condiciones inflamatorias |
| title_full | Estudio del papel de la Laminina Beta 1 en células endoteliales de la barrera hematoencefálica (hCMEC/D3) bajo condiciones inflamatorias |
| title_fullStr | Estudio del papel de la Laminina Beta 1 en células endoteliales de la barrera hematoencefálica (hCMEC/D3) bajo condiciones inflamatorias |
| title_full_unstemmed | Estudio del papel de la Laminina Beta 1 en células endoteliales de la barrera hematoencefálica (hCMEC/D3) bajo condiciones inflamatorias |
| title_short | Estudio del papel de la Laminina Beta 1 en células endoteliales de la barrera hematoencefálica (hCMEC/D3) bajo condiciones inflamatorias |
| title_sort | estudio del papel de la laminina beta 1 en celulas endoteliales de la barrera hematoencefalica hcmec d3 bajo condiciones inflamatorias |
| topic | Barrera hematoencefálica Uniones estrechas Matriz extracelular Inflamación Laminina blood-brain barrier tight junctions extracellular matrix inflammation laminin |
| url | https://repositorio.uan.edu.co/handle/123456789/12193 |
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