Cronación y caracterización de la región promotora del integrón de clase 1 predominante en Colombia, Intl1-Col1
Salmonella enterica subsp. enterica serovar Typhimurium (S. Typhimurium) is a causative agent of gastroenteritis outbreaks, whose clinical relevance has increased due to the emergence of antimicrobial-resistant isolates. In Colombia, the class 1 integron IntI1-Col1 has been predominant in non-invasi...
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| Format: | Tesis/Trabajo de grado - Monografía - Pregrado |
| Language: | Español |
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Universidad Antonio Nariño
2025
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| Online Access: | https://repositorio.uan.edu.co/handle/123456789/12153 |
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| author | Torres Trujillo, Camilo |
| author2 | Wiesner Reyes, Magdalena |
| author_facet | Wiesner Reyes, Magdalena Torres Trujillo, Camilo |
| author_sort | Torres Trujillo, Camilo |
| collection | DSpace |
| description | Salmonella enterica subsp. enterica serovar Typhimurium (S. Typhimurium) is a causative agent of
gastroenteritis outbreaks, whose clinical relevance has increased due to the emergence of
antimicrobial-resistant isolates. In Colombia, the class 1 integron IntI1-Col1 has been predominant
in non-invasive clinical isolates since 1997, containing the gene cassette dfr7-aacA-blaOXA-2. The
type of promoter regulating the expression of these genes, as well as whether their expression is
constitutive or depends on external factors such as antibiotics or environmental conditions, remains
unknown. |
| format | Tesis/Trabajo de grado - Monografía - Pregrado |
| id | repositorio.uan.edu.co-123456789-12153 |
| institution | Repositorio Digital UAN |
| language | Español |
| publishDate | 2025 |
| publisher | Universidad Antonio Nariño |
| record_format | dspace |
| spelling | repositorio.uan.edu.co-123456789-121532025-01-30T15:57:08Z Cronación y caracterización de la región promotora del integrón de clase 1 predominante en Colombia, Intl1-Col1 Torres Trujillo, Camilo Wiesner Reyes, Magdalena Villarreal, José Miguel Florez, Nancy Yaneth Salmonella Typhimurium Resistencia Microbiana Antibióticos Integrones Regiones Promotoras Salmonella Typhimurium Microbial Resistance to Antibiotics, Integrons Promoter Regions Salmonella enterica subsp. enterica serovar Typhimurium (S. Typhimurium) is a causative agent of gastroenteritis outbreaks, whose clinical relevance has increased due to the emergence of antimicrobial-resistant isolates. In Colombia, the class 1 integron IntI1-Col1 has been predominant in non-invasive clinical isolates since 1997, containing the gene cassette dfr7-aacA-blaOXA-2. The type of promoter regulating the expression of these genes, as well as whether their expression is constitutive or depends on external factors such as antibiotics or environmental conditions, remains unknown. Salmonella enterica subsp. enterica serovar Typhimurium (S. Typhimurium) es causante de brotes de gastroenteritis, cuya relevancia clínica se ha incrementado por la emergencia de aislamientos resistentes a antimicrobianos. En Colombia, el integrón de clase 1 IntI1-Col1 es predominante en aislamientos clínicos no invasivos desde 1997, conteniendo el casete de genes dfr7-aacA-blaOXA-2 Se desconoce el tipo de promotor que regula la expresión de estos genes así como si la expresión de estos genes es constitutiva o depende de factores externos como antibióticos o factores ambientales final Biotecnólogo(a) Pregrado Presencial Investigación 2025-01-30T15:57:07Z 2025-01-30T15:57:07Z 2024-11-20 2025-01-30 Tesis/Trabajo de grado - Monografía - Pregrado Estudio descriptivo info:eu-repo/semantics/acceptedVersion http://purl.org/coar/resource_type/c_46ec http://purl.org/redcol/resource_type/PIC http://purl.org/coar/version/c_b1a7d7d4d402bcce https://repositorio.uan.edu.co/handle/123456789/12153 Español info:eu-repo/semantics/openAccess http://purl.org/coar/access_right/c_abf2 pdf application/pdf application/pdf application/pdf Universidad Antonio Nariño Biotecnología Facultad de Ciencias Bogotá - Circunvalar instname:Universidad Antonio Nariño Bai, L., Zhao, J., Gan, X., Wang, J., Zhang, X., Cui, S., Xia, S., Hu, Y., Yan, S., Wang, J., Li, F., Fanning, S., & Xu, J. (2016). Emergence and Diversity of Salmonella enterica Serovar Indiana Isolates with Concurrent Resistance to Ciprofloxacin and Cefotaxime from Patients and Food-Producing Animals in China. Antimicrobial Agents and Chemotherapy, 60(6), 3365–3371. https://doi.org/10.1128/AAC.02849-15 Bhat, B. A., Mir, R. A., Qadri, H., Dhiman, R., Almilaibary, A., Alkhanani, M., & Mir, M. A. (2023). Integrons in the development of antimicrobial resistance: critical review and perspectives. Frontiers in Microbiology, 14, 1231938. https://doi.org/10.3389/fmicb.2023.1231938 Chen, N., Chen, S., Chao, L., Sun, L. N., Zheng, D. M., Liu, Q., & Zhang, Q. (2014). Research of Antibiotics Pollution in Soil Environments and theirs Biological Degradation. Applied Mechanics and Materials, 587–589, 800–803. https://doi.org/10.4028/www.scientific.net/AMM.587-589.800 Collis, C. M., & Hall, R. M. (1995). Expression of antibiotic resistance genes in the integrated cassettes of integrons. Antimicrobial Agents and Chemotherapy, 39(1), 155–162. https://doi.org/10.1128/AAC.39.1.155 Coppens, L., & Lavigne, R. (2020). SAPPHIRE: a neural network based classifier for σ70 promoter prediction in Pseudomonas. BMC Bioinformatics, 21(1), 415. https://doi.org/10.1186/s12859-020-03730-z Czekalski, N., Gascón Díez, E., & Bürgmann, H. (2014). Wastewater as a point source of antibiotic-resistance genes in the sediment of a freshwater lake. The ISME Journal, 8(7), 1381–1390. https://doi.org/10.1038/ismej.2014.8 A. K., Chamorro-Tobar, I. C., Montaño, L. A., Li, Y., Zapata-Bedoya, S., Hinton, J. C. D., Villarreal, J. M., & Wiesner, M. (2023). Class 1 integrons in clinical and swine industry isolates of Salmonella Typhimurium from Colombia, dating 1997 to 2017. Journal of Medical Microbiology, 72(6). https://doi.org/10.1099/jmm.0.001704 Florez, N. Y. (2024). Determinación de elementos genéticos asociados a la resistencia a ampicilina en aislamientos clínicos de Salmonella Typhimurium recuperados a partir del programa de Enfermedad Diarreica Aguda en Colombia entre los años 1997 y 2017 [Doctoral dissertation]. Fonseca, É. L., & Vicente, A. C. (2022). Integron functionality and genome innovation: an update on the subtle and smart strategy of integrase and gene cassette expression regulation. Microorganisms, 10(2). https://doi.org/10.3390/microorganisms10020224 Ghaly, T. M., Tetu, S. G., & Gillings, M. R. (2021). Predicting the taxonomic and environmental sources of integron gene cassettes using structural and sequence homology of attC sites. Communications Biology, 4(1), 946. https://doi.org/10.1038/s42003-021-02489-0 |
| spellingShingle | Salmonella Typhimurium Resistencia Microbiana Antibióticos Integrones Regiones Promotoras Salmonella Typhimurium Microbial Resistance to Antibiotics, Integrons Promoter Regions Torres Trujillo, Camilo Cronación y caracterización de la región promotora del integrón de clase 1 predominante en Colombia, Intl1-Col1 |
| title | Cronación y caracterización de la región promotora del integrón de clase 1 predominante en Colombia, Intl1-Col1 |
| title_full | Cronación y caracterización de la región promotora del integrón de clase 1 predominante en Colombia, Intl1-Col1 |
| title_fullStr | Cronación y caracterización de la región promotora del integrón de clase 1 predominante en Colombia, Intl1-Col1 |
| title_full_unstemmed | Cronación y caracterización de la región promotora del integrón de clase 1 predominante en Colombia, Intl1-Col1 |
| title_short | Cronación y caracterización de la región promotora del integrón de clase 1 predominante en Colombia, Intl1-Col1 |
| title_sort | cronacion y caracterizacion de la region promotora del integron de clase 1 predominante en colombia intl1 col1 |
| topic | Salmonella Typhimurium Resistencia Microbiana Antibióticos Integrones Regiones Promotoras Salmonella Typhimurium Microbial Resistance to Antibiotics, Integrons Promoter Regions |
| url | https://repositorio.uan.edu.co/handle/123456789/12153 |
| work_keys_str_mv | AT torrestrujillocamilo cronacionycaracterizaciondelaregionpromotoradelintegrondeclase1predominanteencolombiaintl1col1 |
