Deterioro Cognitivo tras Administracion de Dosis Subumbrales de Pilocarpina
INTRODUCTION: The present study sought to determine if there is deterioration cognitive function in Wistar rats to which a single subthreshold dose of pilocarpine and that were evaluated using an object recognition test. MATERIAL AND METHODS: Wistar rats (255±34 g) obtained from the National Institu...
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| Format: | Tesis/Trabajo de grado - Monografía - Pregrado |
| Language: | Español |
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Universidad Antonio Nariño
2024
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| Online Access: | https://repositorio.uan.edu.co/handle/123456789/11680 |
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| author | Quiñones Espinosa, Liliana Camila |
| author2 | Javela González, José Julián |
| author_facet | Javela González, José Julián Quiñones Espinosa, Liliana Camila |
| author_sort | Quiñones Espinosa, Liliana Camila |
| collection | DSpace |
| description | INTRODUCTION: The present study sought to determine if there is deterioration
cognitive function in Wistar rats to which a single subthreshold dose of
pilocarpine and that were evaluated using an object recognition test.
MATERIAL AND METHODS: Wistar rats (255±34 g) obtained from the National Institute of
Health and kept in the stable in pairs at a constant temperature (24º±1)
with water and food ad libitum, they were divided into two experimental groups; Group A
(control) to which a single dose of physiological solution was injected (0.9% in 0.5 ml,
i.p) and Group B (experimental) to which a single subthreshold dose of
pilocarpine (200 mg/kg in 0.5 ml, i.p) long-term memory was evaluated by test
object recognition. |
| format | Tesis/Trabajo de grado - Monografía - Pregrado |
| id | repositorio.uan.edu.co-123456789-11680 |
| institution | Repositorio Digital UAN |
| language | Español |
| publishDate | 2024 |
| publisher | Universidad Antonio Nariño |
| record_format | dspace |
| spelling | repositorio.uan.edu.co-123456789-116802024-10-22T15:40:54Z Deterioro Cognitivo tras Administracion de Dosis Subumbrales de Pilocarpina Quiñones Espinosa, Liliana Camila Javela González, José Julián pilocarpina status epiléptico ratas dosis subumbral deterioro cognitivo pilocarpine status epilepticus rats subthreshold dose cognitive impairment INTRODUCTION: The present study sought to determine if there is deterioration cognitive function in Wistar rats to which a single subthreshold dose of pilocarpine and that were evaluated using an object recognition test. MATERIAL AND METHODS: Wistar rats (255±34 g) obtained from the National Institute of Health and kept in the stable in pairs at a constant temperature (24º±1) with water and food ad libitum, they were divided into two experimental groups; Group A (control) to which a single dose of physiological solution was injected (0.9% in 0.5 ml, i.p) and Group B (experimental) to which a single subthreshold dose of pilocarpine (200 mg/kg in 0.5 ml, i.p) long-term memory was evaluated by test object recognition. INTRODUCCION: El presente estudio busco determinar si existe deterioro cognitivo en ratas Wistar a las cuales se les administró una única dosis subumbral de pilocarpina y que fueron evaluadas mediante test de reconocimiento de objetos. MATERIAL Y METODOS: Ratas Wistar (255±34 g) obtenidas del Instituto Nacional De Salud y mantenidas en el estabulario de la en parejas a una temperatura constante (24º±1) con agua y comida ad libitum, fueron divididos en dos grupos experimentales; Grupo A (control) a los cuales se inyecto una única dosis de solución fisiológica (0.9% en 0.5 ml, i.p) y Grupo B (experimental) a los cuales se inyecto una única dosis subumbral de pilocarpina (200 mg/kg en 0.5 ml, i.p) memoria a largo plazo fue evaluado mediante test de reconocimiento de objetos. final Psicólogo(a) Pregrado Presencial Monografía 2024-10-22T15:40:51Z 2024-10-22T15:40:51Z 2016-01-14 2024-10-22 Tesis/Trabajo de grado - Monografía - Pregrado Estudio descriptivo Versión final del autor, Versión aceptada para publicar http://purl.org/coar/resource_type/c_46ec http://purl.org/redcol/resource_type/PIC http://purl.org/coar/version/c_b1a7d7d4d402bcce https://repositorio.uan.edu.co/handle/123456789/11680 Español Acceso abierto http://purl.org/coar/access_right/c_abf2 pdf application/pdf application/pdf Universidad Antonio Nariño Psicología Facultad de Psicología Bogotá - Sur instname:Universidad Antonio Nariño Abel, T., & Lattal, K. (2001) Molecular mechanisms of memory acquisition, consolidation and retrieval. Current Opinion in Neurobiology, 1, 180–187 Ávila Baray, Héctor Luis. Introducción a la metodología de la investigación. En: Eumed.net.http://www.eumed.net/libros/2006c/203/2f.htm Aggleton , J. (1985). One-trial object recognition by rats. Quarterly Journal of Experimental Psychology , 37 (B), 279-294 Aggleton J. & Brown, M. (1999). Episodic memory, amnesia and the hippocampalanterior thalamic axis. Behavioural Brain Science, 22 , 425-444. Adem, A. Jolkkonen, M, Bogdanovic, N. Islam, A. Karlsson, E. (1997). Localization of M1 muscarinic receptors in rat brain using selective muscarinic toxin-1. Brain Res Bull. 44, 597-601. Andrade, R. Andrade, R.C. Malenka, R.A. Nicoll, (1986). A G protein couples serotonin and GABA receptors to the same channels in hippocampus, Science 234: 1261–1265. Andrade R y Nicoll, RA (1987). Pharmacologically distinct actions of serotonin on single pyramidal neurones of the rat hippocampus recorded in vitro. J Physiol, 394: 99-124 Austin JK, David W, Helena MC, Susan MP, Jaroslaw H, Douglas FR. Recurrent seizure and behavior problems in children with first recognised seizures. Epilepsia. 2002;43:1564–75. Aznavour N y Zimmer L. (2007) [18F] MPPF as a tool for the in vivo imaging of 5-HT1A receptors in animal and human brain. Neuropharmacology; 52(3):695-707. Adem, A., Jolkkonen, M., Bogdanovic, N., Islam, A., Karlsson, E., 1997. Localization of M1 muscarinic receptors in rat brain using selective muscarinic toxin-1. Brain Res Bull. 44, 597-601 |
| spellingShingle | pilocarpina status epiléptico ratas dosis subumbral deterioro cognitivo pilocarpine status epilepticus rats subthreshold dose cognitive impairment Quiñones Espinosa, Liliana Camila Deterioro Cognitivo tras Administracion de Dosis Subumbrales de Pilocarpina |
| title | Deterioro Cognitivo tras Administracion de Dosis Subumbrales de Pilocarpina |
| title_full | Deterioro Cognitivo tras Administracion de Dosis Subumbrales de Pilocarpina |
| title_fullStr | Deterioro Cognitivo tras Administracion de Dosis Subumbrales de Pilocarpina |
| title_full_unstemmed | Deterioro Cognitivo tras Administracion de Dosis Subumbrales de Pilocarpina |
| title_short | Deterioro Cognitivo tras Administracion de Dosis Subumbrales de Pilocarpina |
| title_sort | deterioro cognitivo tras administracion de dosis subumbrales de pilocarpina |
| topic | pilocarpina status epiléptico ratas dosis subumbral deterioro cognitivo pilocarpine status epilepticus rats subthreshold dose cognitive impairment |
| url | https://repositorio.uan.edu.co/handle/123456789/11680 |
| work_keys_str_mv | AT quinonesespinosalilianacamila deteriorocognitivotrasadministraciondedosissubumbralesdepilocarpina |
